(R)-3-(4-Hydroxy-2,6-dimethyl-benzyl)-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one

Base Information

Chemical Name:(R)-3-(4-Hydroxy-2,6-dimethyl-benzyl)-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one
CAS No.:955406-34-5
Molecular Formula:C₂₀H₂₅N₃O₂
Molecular Weight:339.437
Hs Code.:

Synonyms:(R)-3-(4-Hydroxy-2,6-dimethyl-benzyl)-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one

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Chemical Property of (R)-3-(4-Hydroxy-2,6-dimethyl-benzyl)-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one

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Technology Process of (R)-3-(4-Hydroxy-2,6-dimethyl-benzyl)-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one

There total 7 articles about (R)-3-(4-Hydroxy-2,6-dimethyl-benzyl)-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 955406-33-4
(R)-3-(4-Benzyloxy-2,6-dimethyl-benzyl)-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one

: 955406-34-5
(R)-3-(4-Hydroxy-2,6-dimethyl-benzyl)-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one

Guidance literature:: With hydrogen; palladium hydroxide on carbon; In ethanol; for 48h; under 1810.07 Torr;

Reference yield:

: 955406-32-3
(R)-4-((R)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-(4-benzyloxy-2,6-dimethyl-benzyl)-4-oxo-butyraldehyde

: 955406-34-5
(R)-3-(4-Hydroxy-2,6-dimethyl-benzyl)-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane; acetonitrile / 1 h / 20 °C

1.2: 20 °C

2.1: hydrogen / palladium hydroxide on carbon / ethanol / 48 h / 1810.07 Torr

With hydrogen; sodium tris(acetoxy)borohydride; palladium hydroxide on carbon; In ethanol; 1,2-dichloro-ethane; acetonitrile;

Reference yield:

: 955406-31-2
(R)-4-Benzyl-3-[(S)-2-(4-benzyloxy-2,6-dimethyl-benzyl)-pent-4-enoyl]-oxazolidin-2-one

: 955406-34-5
(R)-3-(4-Hydroxy-2,6-dimethyl-benzyl)-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium periodate / osmium(VIII) oxide / tetrahydrofuran; water; tert-butyl alcohol / 3 h / 20 °C

2.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane; acetonitrile / 1 h / 20 °C

2.2: 20 °C

3.1: hydrogen / palladium hydroxide on carbon / ethanol / 48 h / 1810.07 Torr

With sodium periodate; hydrogen; sodium tris(acetoxy)borohydride; osmium(VIII) oxide; palladium hydroxide on carbon; In tetrahydrofuran; ethanol; water; 1,2-dichloro-ethane; acetonitrile; tert-butyl alcohol;