(6S,7R,E)-8-(tert-butyldimethylsilyloxy)-7-(dibenzylamino)-6-hydroxyoct-2-en-4-one

Base Information

Chemical Name:(6S,7R,E)-8-(tert-butyldimethylsilyloxy)-7-(dibenzylamino)-6-hydroxyoct-2-en-4-one
CAS No.:1204193-01-0
Molecular Formula:C₂₈H₄₁NO₃Si
Molecular Weight:467.724
Hs Code.:

Synonyms:(6S,7R,E)-8-(tert-butyldimethylsilyloxy)-7-(dibenzylamino)-6-hydroxyoct-2-en-4-one

Suppliers and Price of (6S,7R,E)-8-(tert-butyldimethylsilyloxy)-7-(dibenzylamino)-6-hydroxyoct-2-en-4-one

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Chemical Property of (6S,7R,E)-8-(tert-butyldimethylsilyloxy)-7-(dibenzylamino)-6-hydroxyoct-2-en-4-one

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Technology Process of (6S,7R,E)-8-(tert-butyldimethylsilyloxy)-7-(dibenzylamino)-6-hydroxyoct-2-en-4-one

There total 1 articles about (6S,7R,E)-8-(tert-butyldimethylsilyloxy)-7-(dibenzylamino)-6-hydroxyoct-2-en-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 3102-33-8
trans-3-penten-2-one

: 188840-00-8
(R)-3-(tert-Butyl-dimethyl-silanyloxy)-2-dibenzylamino-propionaldehyde

: 1204193-01-0
(6S,7R,E)-8-(tert-butyldimethylsilyloxy)-7-(dibenzylamino)-6-hydroxyoct-2-en-4-one

Guidance literature:: trans-3-penten-2-one; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.75h; Inert atmosphere;

(R)-3-(tert-Butyl-dimethyl-silanyloxy)-2-dibenzylamino-propionaldehyde; In tetrahydrofuran; at -78 ℃; Inert atmosphere;

With water; ammonium chloride; In tetrahydrofuran; optical yield given as %de; Inert atmosphere;
DOI:10.1021/ol9024138

Reference yield: 96.0%

: 1204193-01-0
(6S,7R,E)-8-(tert-butyldimethylsilyloxy)-7-(dibenzylamino)-6-hydroxyoct-2-en-4-one

: 1204193-02-1
(2R,3S,5R,E)-1-(tert-butyldimethylsilyloxy)-2-(dibenzylamino)oct-6-ene-3,5-diol

Guidance literature:: (6S,7R,E)-8-(tert-butyldimethylsilyloxy)-7-(dibenzylamino)-6-hydroxyoct-2-en-4-one; With diethyl methoxy borane; In tetrahydrofuran; at -78 ℃; for 2h; Inert atmosphere;

With sodium tetrahydroborate; In tetrahydrofuran; at -78 ℃; for 10h; optical yield given as %de; Inert atmosphere;
DOI:10.1021/ol9024138