(2R,3S,5R,E)-1-(tert-butyldimethylsilyloxy)-2-(dibenzylamino)oct-6-ene-3,5-diol

Base Information

Chemical Name:(2R,3S,5R,E)-1-(tert-butyldimethylsilyloxy)-2-(dibenzylamino)oct-6-ene-3,5-diol
CAS No.:1204193-02-1
Molecular Formula:C₂₈H₄₃NO₃Si
Molecular Weight:469.74
Hs Code.:

Synonyms:(2R,3S,5R,E)-1-(tert-butyldimethylsilyloxy)-2-(dibenzylamino)oct-6-ene-3,5-diol

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Chemical Property of (2R,3S,5R,E)-1-(tert-butyldimethylsilyloxy)-2-(dibenzylamino)oct-6-ene-3,5-diol

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Technology Process of (2R,3S,5R,E)-1-(tert-butyldimethylsilyloxy)-2-(dibenzylamino)oct-6-ene-3,5-diol

There total 1 articles about (2R,3S,5R,E)-1-(tert-butyldimethylsilyloxy)-2-(dibenzylamino)oct-6-ene-3,5-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1204193-01-0
(6S,7R,E)-8-(tert-butyldimethylsilyloxy)-7-(dibenzylamino)-6-hydroxyoct-2-en-4-one

: 1204193-02-1
(2R,3S,5R,E)-1-(tert-butyldimethylsilyloxy)-2-(dibenzylamino)oct-6-ene-3,5-diol

Guidance literature:: (6S,7R,E)-8-(tert-butyldimethylsilyloxy)-7-(dibenzylamino)-6-hydroxyoct-2-en-4-one; With diethyl methoxy borane; In tetrahydrofuran; at -78 ℃; for 2h; Inert atmosphere;

With sodium tetrahydroborate; In tetrahydrofuran; at -78 ℃; for 10h; optical yield given as %de; Inert atmosphere;
DOI:10.1021/ol9024138

Reference yield: 81.4%

: 1204193-02-1
(2R,3S,5R,E)-1-(tert-butyldimethylsilyloxy)-2-(dibenzylamino)oct-6-ene-3,5-diol

: 77-76-9
2,2-dimethoxy-propane

: 1204193-09-8
(R)-N,N-dibenzyl-2-(tert-butyldimethylsilyloxy)-1-((4S,6R)-2,2-dimethyl-6-((E)-prop-1-enyl)-1,3-dioxan-4-yl)ethanamine

Guidance literature:: (2R,3S,5R,E)-1-(tert-butyldimethylsilyloxy)-2-(dibenzylamino)oct-6-ene-3,5-diol; 2,2-dimethoxy-propane; With toluene-4-sulfonic acid; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

With sodium hydrogencarbonate; In dichloromethane; for 0.5h; Inert atmosphere;
DOI:10.1021/ol9024138