(E)-(S)-2,4-Bis-benzyloxy-7-methyl-7,8,9,10-tetrahydro-14H-6-oxa-benzocyclododecene-5,13-dione

Base Information

Chemical Name:(E)-(S)-2,4-Bis-benzyloxy-7-methyl-7,8,9,10-tetrahydro-14H-6-oxa-benzocyclododecene-5,13-dione
CAS No.:676604-36-7
Molecular Formula:C₃₀H₃₀O₅
Molecular Weight:470.565
Hs Code.:

Synonyms:(E)-(S)-2,4-Bis-benzyloxy-7-methyl-7,8,9,10-tetrahydro-14H-6-oxa-benzocyclododecene-5,13-dione

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Chemical Property of (E)-(S)-2,4-Bis-benzyloxy-7-methyl-7,8,9,10-tetrahydro-14H-6-oxa-benzocyclododecene-5,13-dione

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Technology Process of (E)-(S)-2,4-Bis-benzyloxy-7-methyl-7,8,9,10-tetrahydro-14H-6-oxa-benzocyclododecene-5,13-dione

There total 8 articles about (E)-(S)-2,4-Bis-benzyloxy-7-methyl-7,8,9,10-tetrahydro-14H-6-oxa-benzocyclododecene-5,13-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 676604-27-6
2,4-Bis-benzyloxy-6-(2-oxo-but-3-enyl)-benzoic acid (S)-1-methyl-hex-5-enyl ester

: 676604-36-7
(E)-(S)-2,4-Bis-benzyloxy-7-methyl-7,8,9,10-tetrahydro-14H-6-oxa-benzocyclododecene-5,13-dione

Guidance literature:: With [1,3-Mes₂-(N₂C₃H₃)]Cl₂(PCy₃)Ru=CHPh; In dichloromethane; for 0.5h; Heating;

Reference yield: 36.0%

: 201230-82-2
carbon monoxide

: C₄₁H₅₇ClO₄Sn

: 676604-36-7
(E)-(S)-2,4-Bis-benzyloxy-7-methyl-7,8,9,10-tetrahydro-14H-6-oxa-benzocyclododecene-5,13-dione

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; trifuran-2-yl-phosphane; In 1,4-dioxane; at 80 ℃;
DOI:10.1038/s41429-019-0145-4

Reference yield:

: 24395-10-6,88932-32-5,88980-13-6,144178-30-3
(R)-hept-6-en-2-ol

: 676604-36-7
(E)-(S)-2,4-Bis-benzyloxy-7-methyl-7,8,9,10-tetrahydro-14H-6-oxa-benzocyclododecene-5,13-dione

Guidance literature:: Multi-step reaction with 3 steps

1: 73 percent / DIAD; P(2-furyl)3 / benzene / 0.17 h / 25 °C

2: 47 percent / Pd(PPh₃)4; P(2-furyl)3 / hexamethylphosphoric acid triamide / 2 h / 80 °C

3: 87 percent / [1,3-Mes₂-(N₂C₃H₃)]Cl₂(PCy₃)Ru=CHPh / CH₂Cl₂ / 0.5 h / Heating

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; trifuran-2-yl-phosphane; di-isopropyl azodicarboxylate; [1,3-Mes₂-(N₂C₃H₃)]Cl₂(PCy₃)Ru=CHPh; In N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane; benzene; 1: Mitsunobu reaction / 2: Stille carbonylative coupling;