methylphenyl N₂-isobutyryl-2'-deoxy-5'-O-dimethoxytritylguanosine-3'-monophosphate

Base Information

• Chemical Name: methylphenyl N₂-isobutyryl-2'-deoxy-5'-O-dimethoxytritylguanosine-3'-monophosphate
• CAS No.: 1360780-30-8
• Molecular Formula: C₄₂H₄₄N₅O₁₀P
• Molecular Weight: 809.813
• Mol file: 1360780-30-8.mol

Synonyms:methylphenyl N₂-isobutyryl-2'-deoxy-5'-O-dimethoxytritylguanosine-3'-monophosphate

Chemical Property of methylphenyl N₂-isobutyryl-2'-deoxy-5'-O-dimethoxytritylguanosine-3'-monophosphate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methylphenyl N₂-isobutyryl-2'-deoxy-5'-O-dimethoxytritylguanosine-3'-monophosphate

There total 3 articles about methylphenyl N₂-isobutyryl-2'-deoxy-5'-O-dimethoxytritylguanosine-3'-monophosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

C42H44N5O9P → methylphenyl N2-isobutyryl-2'-deoxy-5'-O-dimethoxytritylguanosine-3'-monophosphate (1360780-30-8)

Guidance literature:

With tert.-butylhydroperoxide; In 1,4-dioxane; decane; acetonitrile; at 5 ℃; for 0.25h;

DOI:10.1021/jo202505h

Reference yield:

[5'-O-(4,4'-dimethoxytrityl)-N2-isobutyryl-2'-deoxyguanosine-3'-yl]-(N,N'-diisopropyl)methylphosphoramidite (84416-84-2) → methylphenyl N2-isobutyryl-2'-deoxy-5'-O-dimethoxytritylguanosine-3'-monophosphate (1360780-30-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 1H-tetrazole / 1,4-dioxane; acetonitrile / 3.12 h / 5 - 20 °C / Molecular sieve; Sonication

2: tert.-butylhydroperoxide / 1,4-dioxane; decane; acetonitrile / 0.25 h / 5 °C

With 1H-tetrazole; tert.-butylhydroperoxide; In 1,4-dioxane; decane; acetonitrile;

DOI:10.1021/jo202505h

Reference yield:

phenol (108-95-2,27073-41-2) → methylphenyl N2-isobutyryl-2'-deoxy-5'-O-dimethoxytritylguanosine-3'-monophosphate (1360780-30-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 1H-tetrazole / 1,4-dioxane; acetonitrile / 3.12 h / 5 - 20 °C / Molecular sieve; Sonication

2: tert.-butylhydroperoxide / 1,4-dioxane; decane; acetonitrile / 0.25 h / 5 °C

With 1H-tetrazole; tert.-butylhydroperoxide; In 1,4-dioxane; decane; acetonitrile;

DOI:10.1021/jo202505h

upstream raw materials:

[5'-O-(4,4'-dimethoxytrityl)-N₂-isobutyryl-2'-deoxyguanosine-3'-yl]-(N,N'-diisopropyl)methylphosphoramidite

phenol

Downstream raw materials:

phenyl 2'-deoxyguanosine-3'-monophosphate

phenyl-N₂-isobutyryl-2'-deoxyguanosine-3'-monophosphate

C₄₁H₄₂N₅O₁₀P