3-[3,3-dimethyl-4-oxo-4-(7-azabicyclo[2.2.1]heptan-7-yl)butyl]-4-[2-{4-(morpholin-4-ylcarbonyl)piperidin-1-yl}ethyl]-5-(3,5-dimethylphenyl)-1H-pyrrole

Base Information

Chemical Name:3-[3,3-dimethyl-4-oxo-4-(7-azabicyclo[2.2.1]heptan-7-yl)butyl]-4-[2-{4-(morpholin-4-ylcarbonyl)piperidin-1-yl}ethyl]-5-(3,5-dimethylphenyl)-1H-pyrrole
CAS No.:863561-51-7
Molecular Formula:C₃₆H₅₂N₄O₃
Molecular Weight:588.834
Hs Code.:

Synonyms:3-[3,3-dimethyl-4-oxo-4-(7-azabicyclo[2.2.1]heptan-7-yl)butyl]-4-[2-{4-(morpholin-4-ylcarbonyl)piperidin-1-yl}ethyl]-5-(3,5-dimethylphenyl)-1H-pyrrole

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Chemical Property of 3-[3,3-dimethyl-4-oxo-4-(7-azabicyclo[2.2.1]heptan-7-yl)butyl]-4-[2-{4-(morpholin-4-ylcarbonyl)piperidin-1-yl}ethyl]-5-(3,5-dimethylphenyl)-1H-pyrrole

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Technology Process of 3-[3,3-dimethyl-4-oxo-4-(7-azabicyclo[2.2.1]heptan-7-yl)butyl]-4-[2-{4-(morpholin-4-ylcarbonyl)piperidin-1-yl}ethyl]-5-(3,5-dimethylphenyl)-1H-pyrrole

There total 14 articles about 3-[3,3-dimethyl-4-oxo-4-(7-azabicyclo[2.2.1]heptan-7-yl)butyl]-4-[2-{4-(morpholin-4-ylcarbonyl)piperidin-1-yl}ethyl]-5-(3,5-dimethylphenyl)-1H-pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 666850-79-9
2-[1,1-dimethyl-2-oxo-2-(7-azabicyclo[2.2.1]heptan-7-yl)ethyl]-4-[2-(4-{morpholinocarbonyl}piperidin-1-yl)ethyl]-5-(3,5-dimethylphenyl)-6H-thieno[2,3-b]pyrrole

: 863561-51-7
3-[3,3-dimethyl-4-oxo-4-(7-azabicyclo[2.2.1]heptan-7-yl)butyl]-4-[2-{4-(morpholin-4-ylcarbonyl)piperidin-1-yl}ethyl]-5-(3,5-dimethylphenyl)-1H-pyrrole

Guidance literature:: With hydrogen; nickel; In ethanol; at 20 ℃; for 16h; under 1292.09 Torr;

Reference yield:

: 666852-77-3
2-[5-(3,5-dimethylphenyl)-4-(2-hydroxyethyl)-6H-thieno[2,3-b]pyrrol-2-yl]-2-methylpropanoic acid

: 863561-51-7
3-[3,3-dimethyl-4-oxo-4-(7-azabicyclo[2.2.1]heptan-7-yl)butyl]-4-[2-{4-(morpholin-4-ylcarbonyl)piperidin-1-yl}ethyl]-5-(3,5-dimethylphenyl)-1H-pyrrole

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 2.25 h / 0 - 20 °C

2: thionyl chloride / dichloromethane / 2 h / 0 - 20 °C

3: potassium carbonate; sodium iodide / ISOPROPYLAMIDE / 6 h / 85 °C

4: hydrogen / nickel / ethanol / 16 h / 20 °C / 1292.09 Torr

With thionyl chloride; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; sodium iodide; nickel; In ethanol; dichloromethane; ISOPROPYLAMIDE;

Reference yield:

: ethyl 2-[5-(3,5-dimethylphenyl)-4-(2-hydroxyethyl)-6H-thieno[2,3-b]pyrrol-2-yl]-2-methylpropanoate

: 863561-51-7
3-[3,3-dimethyl-4-oxo-4-(7-azabicyclo[2.2.1]heptan-7-yl)butyl]-4-[2-{4-(morpholin-4-ylcarbonyl)piperidin-1-yl}ethyl]-5-(3,5-dimethylphenyl)-1H-pyrrole

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide; water / ethanol / 4 h / 60 °C

1.2: 5 °C / pH 1

2.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 2.25 h / 0 - 20 °C

3.1: thionyl chloride / dichloromethane / 2 h / 0 - 20 °C

4.1: potassium carbonate; sodium iodide / ISOPROPYLAMIDE / 6 h / 85 °C

5.1: hydrogen / nickel / ethanol / 16 h / 20 °C / 1292.09 Torr

With sodium hydroxide; thionyl chloride; water; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; sodium iodide; nickel; In ethanol; dichloromethane; ISOPROPYLAMIDE;