C₅₄H₆₆N₄O₂₁

Base Information

• Chemical Name: C₅₄H₆₆N₄O₂₁
• CAS No.: 186972-20-3
• Molecular Formula: C₅₄H₆₆N₄O₂₁
• Molecular Weight: 1107.13
• Mol file: 186972-20-3.mol

Synonyms:C₅₄H₆₆N₄O₂₁

Chemical Property of C₅₄H₆₆N₄O₂₁

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₅₄H₆₆N₄O₂₁

There total 8 articles about C₅₄H₆₆N₄O₂₁ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzaldehyde dimethyl acetal (1125-88-8) → C54H66N4O21 (186972-20-3)

Guidance literature:

Multi-step reaction with 5 steps

1: camphorsulfonic acid / dimethylformamide / 2 h / 20 °C

2: 81 percent / TMSOTf, MS 4A / CH₂Cl₂ / 1.5 h / -20 °C

3: 64 percent / (C₅H₅)2ZrCl₂, AgClO₄, MS 4A / CH₂Cl₂ / 3 h / -20 - -10 °C

4: NiCl₂*6H₂O, B(OH)3, NaBH₄ / ethanol / 1 h / 0 °C

5: ethanol / 2 h / 20 °C

With sodium tetrahydroborate; zirconocene dichloride; trimethylsilyl trifluoromethanesulfonate; camphor-10-sulfonic acid; boric acid; silver perchlorate; nickel dichloride; In ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1039/cc9960002779

Reference yield:

1,3,4,6-tetra-O-acetyl-2-azido-2-deoxy-D-galactopyranose (84278-00-2) → C54H66N4O21 (186972-20-3)

Guidance literature:

Multi-step reaction with 7 steps

1: 1.) BnNH₂, 2.) diethylaminosulfur trifluoride / 1.) THF, 20 deg C, 2 h, 2.) 20 deg C, 3 h

2: NaOMe / methanol; tetrahydrofuran / 2 h / 20 °C

3: camphorsulfonic acid / dimethylformamide / 2 h / 20 °C

4: 81 percent / TMSOTf, MS 4A / CH₂Cl₂ / 1.5 h / -20 °C

5: 64 percent / (C₅H₅)2ZrCl₂, AgClO₄, MS 4A / CH₂Cl₂ / 3 h / -20 - -10 °C

6: NiCl₂*6H₂O, B(OH)3, NaBH₄ / ethanol / 1 h / 0 °C

7: ethanol / 2 h / 20 °C

With sodium tetrahydroborate; zirconocene dichloride; diethylamino-sulfur trifluoride; trimethylsilyl trifluoromethanesulfonate; camphor-10-sulfonic acid; sodium methylate; boric acid; silver perchlorate; benzylamine; nickel dichloride; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1039/cc9960002779

Reference yield:

(2R,3R,4R,5R)-5-Azido-6-fluoro-2-hydroxymethyl-tetrahydro-pyran-3,4-diol → C54H66N4O21 (186972-20-3)

Guidance literature:

Multi-step reaction with 5 steps

1: camphorsulfonic acid / dimethylformamide / 2 h / 20 °C

2: 81 percent / TMSOTf, MS 4A / CH₂Cl₂ / 1.5 h / -20 °C

3: 64 percent / (C₅H₅)2ZrCl₂, AgClO₄, MS 4A / CH₂Cl₂ / 3 h / -20 - -10 °C

4: NiCl₂*6H₂O, B(OH)3, NaBH₄ / ethanol / 1 h / 0 °C

5: ethanol / 2 h / 20 °C

With sodium tetrahydroborate; zirconocene dichloride; trimethylsilyl trifluoromethanesulfonate; camphor-10-sulfonic acid; boric acid; silver perchlorate; nickel dichloride; In ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1039/cc9960002779

upstream raw materials:

acetic anhydride

benzaldehyde dimethyl acetal

1,3,4,6-tetra-O-acetyl-2-azido-2-deoxy-D-galactopyranose

(2S,4aR,7R,8R,8aR)-7-Azido-6-fluoro-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-8-ol