[(3S,4S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-oxo-4-((S)-1-phenylsulfanylcarbonyl-ethyl)-azetidin-1-yl]-acetic acid 4-nitro-benzyl ester

Base Information

Chemical Name:[(3S,4S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-oxo-4-((S)-1-phenylsulfanylcarbonyl-ethyl)-azetidin-1-yl]-acetic acid 4-nitro-benzyl ester
CAS No.:161023-73-0
Molecular Formula:C₂₉H₃₈N₂O₇SSi
Molecular Weight:586.781
Hs Code.:

Synonyms:[(3S,4S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-oxo-4-((S)-1-phenylsulfanylcarbonyl-ethyl)-azetidin-1-yl]-acetic acid 4-nitro-benzyl ester

Suppliers and Price of [(3S,4S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-oxo-4-((S)-1-phenylsulfanylcarbonyl-ethyl)-azetidin-1-yl]-acetic acid 4-nitro-benzyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of [(3S,4S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-oxo-4-((S)-1-phenylsulfanylcarbonyl-ethyl)-azetidin-1-yl]-acetic acid 4-nitro-benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of [(3S,4S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-oxo-4-((S)-1-phenylsulfanylcarbonyl-ethyl)-azetidin-1-yl]-acetic acid 4-nitro-benzyl ester

There total 9 articles about [(3S,4S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-oxo-4-((S)-1-phenylsulfanylcarbonyl-ethyl)-azetidin-1-yl]-acetic acid 4-nitro-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 97101-07-0
(3S,4S)-3-<(1R)-1-<(tert-Butyldimethylsilyl)oxy>ethyl>-4-<(1S)-1-carboxyethyl>azetidin-2-one

: 161023-73-0
[(3S,4S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-oxo-4-((S)-1-phenylsulfanylcarbonyl-ethyl)-azetidin-1-yl]-acetic acid 4-nitro-benzyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 90 percent / K₂CO₃ / acetone / 4 h / Heating

2: NaH / tetrahydrofuran / 2 h / 0 °C

3: H₂ / 10percent Pd/C / ethanol / 760 Torr / Ambient temperature

4: Et₃N / CH₂Cl₂ / 1 h

5: CH₂Cl₂ / 1 h

6: anisole, TiCl₄ / CH₂Cl₂ / 1 h / 0 °C

7: γ-collidine / dimethylformamide / 1.5 h / 65 °C

8: imidazole / dimethylformamide / 5 h

With 1H-imidazole; 2,4,6-trimethyl-pyridine; hydrogen; titanium tetrachloride; sodium hydride; potassium carbonate; methoxybenzene; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1248/cpb.42.1381

Reference yield:

: 96035-98-2,96093-92-4
(3S,4S)-4-<(1S)-1-benzyloxycarbonylethyl>-3-<(1R)-1-tert-butyldimethylsilyloxyethyl>-2-azetidinone

: 161023-73-0
[(3S,4S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-oxo-4-((S)-1-phenylsulfanylcarbonyl-ethyl)-azetidin-1-yl]-acetic acid 4-nitro-benzyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: NaH / tetrahydrofuran / 2 h / 0 °C

2: H₂ / 10percent Pd/C / ethanol / 760 Torr / Ambient temperature

3: Et₃N / CH₂Cl₂ / 1 h

4: CH₂Cl₂ / 1 h

5: anisole, TiCl₄ / CH₂Cl₂ / 1 h / 0 °C

6: γ-collidine / dimethylformamide / 1.5 h / 65 °C

7: imidazole / dimethylformamide / 5 h

With 1H-imidazole; 2,4,6-trimethyl-pyridine; hydrogen; titanium tetrachloride; sodium hydride; methoxybenzene; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.42.1381

Reference yield:

: 105370-87-4
(3S,4S)-4-<(1S)-1-benzyloxycarbonylethyl>1-(tert-butoxycarbonylmethyl)-3-<(1R)-1-tert-butyldimethylsilyloxy>-2-azetidinone

: 161023-73-0
[(3S,4S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-oxo-4-((S)-1-phenylsulfanylcarbonyl-ethyl)-azetidin-1-yl]-acetic acid 4-nitro-benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: H₂ / 10percent Pd/C / ethanol / 760 Torr / Ambient temperature

2: Et₃N / CH₂Cl₂ / 1 h

3: CH₂Cl₂ / 1 h

4: anisole, TiCl₄ / CH₂Cl₂ / 1 h / 0 °C

5: γ-collidine / dimethylformamide / 1.5 h / 65 °C

6: imidazole / dimethylformamide / 5 h

With 1H-imidazole; 2,4,6-trimethyl-pyridine; hydrogen; titanium tetrachloride; methoxybenzene; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.42.1381