tert-butyl (4-(2-(bromomethyl)phenyl)-1-phenylbutan-2-yl)carbamate

Base Information

Chemical Name:tert-butyl (4-(2-(bromomethyl)phenyl)-1-phenylbutan-2-yl)carbamate
CAS No.:1433993-14-6
Molecular Formula:C₂₂H₂₈BrNO₂
Molecular Weight:418.374
Hs Code.:

Synonyms:tert-butyl (4-(2-(bromomethyl)phenyl)-1-phenylbutan-2-yl)carbamate

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Chemical Property of tert-butyl (4-(2-(bromomethyl)phenyl)-1-phenylbutan-2-yl)carbamate

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Technology Process of tert-butyl (4-(2-(bromomethyl)phenyl)-1-phenylbutan-2-yl)carbamate

There total 10 articles about tert-butyl (4-(2-(bromomethyl)phenyl)-1-phenylbutan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1433993-13-5
tert-butyl (4-(2-(hydroxymethyl)phenyl)-1-phenylbutan-2-yl)carbamate

: 1433993-14-6
tert-butyl (4-(2-(bromomethyl)phenyl)-1-phenylbutan-2-yl)carbamate

Guidance literature:: With N-Bromosuccinimide; triphenylphosphine; In dichloromethane; at 20 ℃;

Reference yield:

: 122-78-1
phenylacetaldehyde

: 1433993-14-6
tert-butyl (4-(2-(bromomethyl)phenyl)-1-phenylbutan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 10 steps

1.1: n-butyllithium / tetrahydrofuran / 0.33 h / -78 °C

1.2: 0.83 h / -78 °C

2.1: sodium carbonate / dichloromethane; methanol / 20 °C

3.1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / 2 h / 20 °C / Inert atmosphere

4.1: hydrogen; palladium 10% on activated carbon / methanol / 760.05 Torr

5.1: triethylamine / 0 - 20 °C

6.1: 15-crown-5; sodium azide / N,N-dimethyl-formamide / 24 h / 85 °C / Inert atmosphere

7.1: hydrogen; palladium 10% on activated carbon / methanol / 760.05 Torr

8.1: triethylamine / dichloromethane / 0 - 20 °C

9.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C

10.1: N-Bromosuccinimide; triphenylphosphine / dichloromethane / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; N-Bromosuccinimide; copper(l) iodide; lithium aluminium tetrahydride; n-butyllithium; sodium azide; 15-crown-5; palladium 10% on activated carbon; hydrogen; sodium carbonate; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1433993-09-9
methyl 2-(3-((methylsulfonyl)oxy)-4-phenylbutyl)benzoate

: 1433993-14-6
tert-butyl (4-(2-(bromomethyl)phenyl)-1-phenylbutan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1: 15-crown-5; sodium azide / N,N-dimethyl-formamide / 24 h / 85 °C / Inert atmosphere

2: hydrogen; palladium 10% on activated carbon / methanol / 760.05 Torr

3: triethylamine / dichloromethane / 0 - 20 °C

4: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C

5: N-Bromosuccinimide; triphenylphosphine / dichloromethane / 20 °C

With N-Bromosuccinimide; lithium aluminium tetrahydride; sodium azide; 15-crown-5; palladium 10% on activated carbon; hydrogen; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;