Technology Process of methyl 4-oxo-6-(m-tolylethynyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxylate
There total 4 articles about methyl 4-oxo-6-(m-tolylethynyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
6-(m-tolylethynyl)-2,3-dihydro-1,8-naphthyridin-4(1H)-one;
With
lithium hexamethyldisilazane;
In
tetrahydrofuran;
at -75 ℃;
Inert atmosphere;
methyl chloroformate;
In
tetrahydrofuran;
at -75 - 0 ℃;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: toluene / 72 h / Reflux
2.1: trifluorormethanesulfonic acid / 3 h / 90 °C
3.1: triethylamine; tri-tert-butyl phosphine / N,N-dimethyl-formamide / 0.08 h / 20 °C / Inert atmosphere
3.2: 0.17 h / 20 °C / Inert atmosphere
3.3: 20 - 80 °C / Inert atmosphere
4.1: lithium hexamethyldisilazane / tetrahydrofuran / -75 °C / Inert atmosphere
4.2: -75 - 0 °C / Inert atmosphere
With
tri-tert-butyl phosphine; trifluorormethanesulfonic acid; triethylamine; lithium hexamethyldisilazane;
In
tetrahydrofuran; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: trifluorormethanesulfonic acid / 3 h / 90 °C
2.1: triethylamine; tri-tert-butyl phosphine / N,N-dimethyl-formamide / 0.08 h / 20 °C / Inert atmosphere
2.2: 0.17 h / 20 °C / Inert atmosphere
2.3: 20 - 80 °C / Inert atmosphere
3.1: lithium hexamethyldisilazane / tetrahydrofuran / -75 °C / Inert atmosphere
3.2: -75 - 0 °C / Inert atmosphere
With
tri-tert-butyl phosphine; trifluorormethanesulfonic acid; triethylamine; lithium hexamethyldisilazane;
In
tetrahydrofuran; N,N-dimethyl-formamide;
