Technology Process of 4-(5-(1,3-dioxolan-2-yl)-2-fluoropyridin-3-yl)-N,N-bis-(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine
There total 5 articles about 4-(5-(1,3-dioxolan-2-yl)-2-fluoropyridin-3-yl)-N,N-bis-(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); potassium acetate;
In
1,4-dioxane; water;
at 100 ℃;
for 4h;
Inert atmosphere;
DOI:10.1021/jm300184s
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: toluene-4-sulfonic acid / toluene / 0.75 h / 120 °C / Inert atmosphere
2.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane; ethylbenzene / 1.58 h / Inert atmosphere; Cooling with acetone-dry ice
2.2: 4.5 h / 22 °C / Inert atmosphere; Cooling with acetone-dry ice
3.1: sodium hydroxide / tetrahydrofuran; n-heptane; ethylbenzene; water / 22 °C
3.2: pH 5
4.1: magnesium sulfate / toluene / 72 h / 22 °C / Inert atmosphere
5.1: bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); potassium acetate / 1,4-dioxane; water / 4 h / 100 °C / Inert atmosphere
With
bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); potassium acetate; magnesium sulfate; toluene-4-sulfonic acid; sodium hydroxide; lithium diisopropyl amide;
In
tetrahydrofuran; 1,4-dioxane; n-heptane; ethylbenzene; water; toluene;
5.1: Suzuki-Miyaura cross-coupling;
DOI:10.1021/jm300184s
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane; ethylbenzene / 1.58 h / Inert atmosphere; Cooling with acetone-dry ice
1.2: 4.5 h / 22 °C / Inert atmosphere; Cooling with acetone-dry ice
2.1: sodium hydroxide / tetrahydrofuran; n-heptane; ethylbenzene; water / 22 °C
2.2: pH 5
3.1: magnesium sulfate / toluene / 72 h / 22 °C / Inert atmosphere
4.1: bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); potassium acetate / 1,4-dioxane; water / 4 h / 100 °C / Inert atmosphere
With
bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); potassium acetate; magnesium sulfate; sodium hydroxide; lithium diisopropyl amide;
In
tetrahydrofuran; 1,4-dioxane; n-heptane; ethylbenzene; water; toluene;
4.1: Suzuki-Miyaura cross-coupling;
DOI:10.1021/jm300184s
