(1'R,2'R,3'S)-9-[2',3'-bis(benzoyloxymethyl)cyclobutyl]-N²-isobutylguanine

Base Information

Chemical Name:(1'R,2'R,3'S)-9-[2',3'-bis(benzoyloxymethyl)cyclobutyl]-N²-isobutylguanine
CAS No.:283597-99-9
Molecular Formula:C₂₉H₂₉N₅O₆
Molecular Weight:543.579
Hs Code.:

(1'R,2'R,3'S)-9-[2',3'-bis(benzoyloxymethyl)cyclobutyl]-N<sup>2</sup>-isobutylguanine

Synonyms:(1'R,2'R,3'S)-9-[2',3'-bis(benzoyloxymethyl)cyclobutyl]-N²-isobutylguanine

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Chemical Property of (1'R,2'R,3'S)-9-[2',3'-bis(benzoyloxymethyl)cyclobutyl]-N²-isobutylguanine

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Technology Process of (1'R,2'R,3'S)-9-[2',3'-bis(benzoyloxymethyl)cyclobutyl]-N²-isobutylguanine

There total 1 articles about (1'R,2'R,3'S)-9-[2',3'-bis(benzoyloxymethyl)cyclobutyl]-N²-isobutylguanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 132294-18-9
<1S-(1α,2β,3β)>-3-<<(4-methylphenyl)sulfonyl>oxy>-1,2-cyclobutanedimethanol dibenzoate ester

: 79-30-1
isobutyryl chloride

: 10310-21-1
2-Amino-6-chloropurin

: 283597-99-9
(1'R,2'R,3'S)-9-[2',3'-bis(benzoyloxymethyl)cyclobutyl]-N²-isobutylguanine

Guidance literature:: <1S-(1α,2β,3β)>-3-<<(4-methylphenyl)sulfonyl>oxy>-1,2-cyclobutanedimethanol dibenzoate ester; 2-Amino-6-chloropurin; In N,N-dimethyl-formamide; at 100 ℃; for 10h;

With trifluoroacetic acid; In water; at 20 ℃; for 12h;

isobutyryl chloride; With pyridine; at 0 ℃; for 0.5h;
DOI:10.1016/S0040-4020(00)00162-9

Reference yield: 75.0%

: 283597-99-9
(1'R,2'R,3'S)-9-[2',3'-bis(benzoyloxymethyl)cyclobutyl]-N²-isobutylguanine

: 283598-03-8
(1'R,2'R,3'S)-9-[2'-benzoyloxymethyl-3'-(hydroxymethyl)cyclobutyl]-N²-isobutyrylguanine

Guidance literature:: With Lipase MY; In phosphate buffer; acetone; at 36 ℃; for 192h; pH=7.0; Enzymatic reaction;
DOI:10.1016/S0040-4020(00)00162-9

Reference yield:

: 283597-99-9
(1'R,2'R,3'S)-9-[2',3'-bis(benzoyloxymethyl)cyclobutyl]-N²-isobutylguanine

: (1'R,2'R,3'S)-9-{2'-hydroxymethyl-3'-[bis(p-methoxyphenyl)phenylmethyloxymethyl]cyclobutyl}-N²-(N,N-dimethylaminomethylene)guanine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 75 percent / lipase MY / acetone; aq. phosphate buffer / 192 h / 36 °C / pH 7.0 / Enzymatic reaction

2.1: Py / 12 h / 20 °C

2.2: NaOH / methanol; H₂O

2.3: 72 percent / methanol / 12 h / 20 °C

With pyridine; Lipase MY; In phosphate buffer; acetone; 1.1: Hydrolysis / 2.1: Substitution / 2.2: Hydrolysis / 2.3: Condensation;
DOI:10.1016/S0040-4020(00)00162-9