[5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-(2-phenylethyl)-1H-benzimidazol-1-yl]acetaldehyde

Base Information

Chemical Name:[5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-(2-phenylethyl)-1H-benzimidazol-1-yl]acetaldehyde
CAS No.:1613695-19-4
Molecular Formula:C₂₂H₂₁N₃O₂
Molecular Weight:359.428
Hs Code.:

Synonyms:[5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-(2-phenylethyl)-1H-benzimidazol-1-yl]acetaldehyde

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Chemical Property of [5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-(2-phenylethyl)-1H-benzimidazol-1-yl]acetaldehyde

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Technology Process of [5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-(2-phenylethyl)-1H-benzimidazol-1-yl]acetaldehyde

There total 5 articles about [5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-(2-phenylethyl)-1H-benzimidazol-1-yl]acetaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1613694-61-3
1-(2,2-dimethoxyethyl)-5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-(2-phenylethyl)-1H-benzimidazole

: 1613695-19-4
[5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-(2-phenylethyl)-1H-benzimidazol-1-yl]acetaldehyde

Guidance literature:: With trifluoroacetic acid; In dichloromethane; water; at 150 ℃; for 0.833333h; Microwave irradiation;
DOI:10.1021/ja412434f

Reference yield:

: 364-73-8
4-Bromo-1-fluoro-2-nitrobenzene

: 1613695-19-4
[5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-(2-phenylethyl)-1H-benzimidazol-1-yl]acetaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II); sodium hydrogencarbonate / 1,2-dimethoxyethane / 3 h / 80 °C / Inert atmosphere

2: dimethyl sulfoxide / 2 h / 80 °C

3: sodium dithionite / methanol / 2 h / 80 °C

4: trifluoroacetic acid / water; dichloromethane / 0.83 h / 150 °C / Microwave irradiation

With sodium dithionite; [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II); sodium hydrogencarbonate; trifluoroacetic acid; In methanol; 1,2-dimethoxyethane; dichloromethane; water; dimethyl sulfoxide; 1: |Suzuki Coupling;
DOI:10.1021/ja412434f

Reference yield:

: 832114-00-8
3,5-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoxazole

: 1613695-19-4
[5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-(2-phenylethyl)-1H-benzimidazol-1-yl]acetaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II); sodium hydrogencarbonate / 1,2-dimethoxyethane / 3 h / 80 °C / Inert atmosphere

2: dimethyl sulfoxide / 2 h / 80 °C

3: sodium dithionite / methanol / 2 h / 80 °C

4: trifluoroacetic acid / water; dichloromethane / 0.83 h / 150 °C / Microwave irradiation

With sodium dithionite; [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II); sodium hydrogencarbonate; trifluoroacetic acid; In methanol; 1,2-dimethoxyethane; dichloromethane; water; dimethyl sulfoxide; 1: |Suzuki Coupling;
DOI:10.1021/ja412434f