1-(2,2-dimethoxyethyl)-5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-(2-phenylethyl)-1H-benzimidazole

Base Information

Chemical Name:1-(2,2-dimethoxyethyl)-5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-(2-phenylethyl)-1H-benzimidazole
CAS No.:1613694-61-3
Molecular Formula:C₂₄H₂₇N₃O₃
Molecular Weight:405.497
Hs Code.:

Synonyms:1-(2,2-dimethoxyethyl)-5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-(2-phenylethyl)-1H-benzimidazole

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Chemical Property of 1-(2,2-dimethoxyethyl)-5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-(2-phenylethyl)-1H-benzimidazole

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Technology Process of 1-(2,2-dimethoxyethyl)-5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-(2-phenylethyl)-1H-benzimidazole

There total 5 articles about 1-(2,2-dimethoxyethyl)-5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-(2-phenylethyl)-1H-benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 104-53-0
3-phenyl-propionaldehyde

: C₁₅H₁₉N₃O₅

: 1613694-61-3
1-(2,2-dimethoxyethyl)-5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-(2-phenylethyl)-1H-benzimidazole

Guidance literature:: With sodium dithionite; In methanol; at 80 ℃; for 2h;
DOI:10.1021/ja412434f

Reference yield: 53.0%

: 104-53-0
3-phenyl-propionaldehyde

: 1428368-75-5
4-(4-fluoro-3-nitrophenyl)-3,5-dimethyl-1,2-oxazole

: 22483-09-6
2,2-dimethoxyethylamine

: 1613694-61-3
1-(2,2-dimethoxyethyl)-5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-(2-phenylethyl)-1H-benzimidazole

Guidance literature:: 4-(4-fluoro-3-nitrophenyl)-3,5-dimethyl-1,2-oxazole; 2,2-dimethoxyethylamine; In dimethyl sulfoxide; at 80 ℃; for 3h;

3-phenyl-propionaldehyde; With sodium dithionite; In dimethyl sulfoxide; at 80 ℃; for 9h;
DOI:10.1002/chem.202102036

Reference yield:

: 364-73-8
4-Bromo-1-fluoro-2-nitrobenzene

: 1613694-61-3
1-(2,2-dimethoxyethyl)-5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-(2-phenylethyl)-1H-benzimidazole

Guidance literature:: Multi-step reaction with 3 steps

1: [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II); sodium hydrogencarbonate / 1,2-dimethoxyethane / 3 h / 80 °C / Inert atmosphere

2: dimethyl sulfoxide / 2 h / 80 °C

3: sodium dithionite / methanol / 2 h / 80 °C

With sodium dithionite; [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II); sodium hydrogencarbonate; In methanol; 1,2-dimethoxyethane; dimethyl sulfoxide; 1: |Suzuki Coupling;
DOI:10.1021/ja412434f