5-nitro-2-pyrrolidin-1-ylbenzonitrile

Base Information

• Chemical Name: 5-nitro-2-pyrrolidin-1-ylbenzonitrile
• CAS No.: 17615-42-8
• Molecular Formula: C₁₁H₁₁N₃O₂
• Molecular Weight: 217.227
• Mol file: 17615-42-8.mol

Synonyms:1-pyrrolidino-4-nitro-2-cyanobenzene

Chemical Property of 5-nitro-2-pyrrolidin-1-ylbenzonitrile

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

5-Nitro-2-pyrrolidin-1-ylbenzonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-nitro-2-pyrrolidin-1-ylbenzonitrile

There total 4 articles about 5-nitro-2-pyrrolidin-1-ylbenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

pyrrolidine (123-75-1) + 4-chloro-3-cyanonitrobenzene (16588-02-6) → 1-pyrrolidino-4-nitro-2-cyanobenzene (17615-42-8)

Guidance literature:

In ethanol; for 2h; Heating;

DOI:10.1021/jm9810349

Reference yield: 60.0%

5-nitro-2-(1-pyrrolidinyl)-benzaldehyde (30742-59-7) → 1-pyrrolidino-4-nitro-2-cyanobenzene (17615-42-8)

Guidance literature:

With hydroxylamine hydrochloride; In ethanol; at 150 ℃; for 18h;

DOI:10.1021/ol300303s

Reference yield: 38.0%

pyrrolidine (123-75-1) + 4-Nitrophthalonitrile (31643-49-9) → 1-pyrrolidino-4-nitro-2-cyanobenzene (17615-42-8) + 1-pyrrolidino-2,3,5-tricyanobenzene (123647-06-3) + 1-pyrrolidino-2,4,5-tricyanobenzene (123647-05-2)

Guidance literature:

In various solvent(s); for 1h; Ambient temperature;

upstream raw materials:

pyrrolidine

4-Nitrophthalonitrile

4-chloro-3-cyanonitrobenzene

2-fluoro-5-nitrobenzaldehye

Downstream raw materials:

5-amino-2-pyrrolidino-benzonitrile

N-(3-cyano-4-pyrrolidinophenyl)-1-(4-fluorophenyl)-5-methylpyrazole-4-carboxamide

1-(4-chlorophenyl)-N-(3-cyano-4-pyrrolidinophenyl)-5-methylpyrazole-4-carboxamide

methyl 4-<2-<<1-<5-chloro-2-(1-pyrrolidinyl)phenyl>ethyl>amino>-2-oxoethyl>-benzoate

Refernces

• 1、 Crampton, Michael R.,Emokpae, Thomas A.,Isanbor, Chukwuemeka. "The effects of ring substituents and leaving groups on the kinetics of SNAr reactions of 1-halogeno- and 1-phenoxy-nitrobenzenes with aliphatic amines in acetonitrile". . p. 1378 - 1383. Retrieved 2008/09/18.
• 2、 Berzin'sh, E. L.,Roze, M. P.,Neiland, O. Ya.,Gavar, P.. "REACTION OF 4-NITROPHTHALONITRILE WITH PYRROLIDINE". . p. 599 - 600. Retrieved 2007/10/02.