(S)-2-(3-Isobutyl-3-methyl-ureido)-3-[4-(5-methoxy-2-methyl-3-oxo-2,3-dihydro-pyridazin-4-yl)-phenyl]-propionic acid

Base Information

Chemical Name:(S)-2-(3-Isobutyl-3-methyl-ureido)-3-[4-(5-methoxy-2-methyl-3-oxo-2,3-dihydro-pyridazin-4-yl)-phenyl]-propionic acid
CAS No.:862854-00-0
Molecular Formula:C₂₁H₂₈N₄O₅
Molecular Weight:416.477
Hs Code.:

Synonyms:(S)-2-(3-Isobutyl-3-methyl-ureido)-3-[4-(5-methoxy-2-methyl-3-oxo-2,3-dihydro-pyridazin-4-yl)-phenyl]-propionic acid

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Chemical Property of (S)-2-(3-Isobutyl-3-methyl-ureido)-3-[4-(5-methoxy-2-methyl-3-oxo-2,3-dihydro-pyridazin-4-yl)-phenyl]-propionic acid

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Technology Process of (S)-2-(3-Isobutyl-3-methyl-ureido)-3-[4-(5-methoxy-2-methyl-3-oxo-2,3-dihydro-pyridazin-4-yl)-phenyl]-propionic acid

There total 5 articles about (S)-2-(3-Isobutyl-3-methyl-ureido)-3-[4-(5-methoxy-2-methyl-3-oxo-2,3-dihydro-pyridazin-4-yl)-phenyl]-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₂H₃₀N₄O₅

: 862854-00-0
(S)-2-(3-Isobutyl-3-methyl-ureido)-3-[4-(5-methoxy-2-methyl-3-oxo-2,3-dihydro-pyridazin-4-yl)-phenyl]-propionic acid

Guidance literature:: C₂₂H₃₀N₄O₅; With lithium hydroxide; water; In tetrahydrofuran; methanol; at 23 ℃; for 2h;

With hydrogenchloride; In water; pH=2;

Reference yield:

: 862854-55-5
(S)-2[(imidazole-1-carbonyl)-amino]-3-[4-(5-methoxy-2-methyl-3-oxo-2,3-dihydro-pyridazin-4-yl)-phenyl]-propionic acid methyl ester

: 625-43-4
2-methylpropyl(methyl)amine

: 862854-00-0
(S)-2-(3-Isobutyl-3-methyl-ureido)-3-[4-(5-methoxy-2-methyl-3-oxo-2,3-dihydro-pyridazin-4-yl)-phenyl]-propionic acid

Guidance literature:: (S)-2[(imidazole-1-carbonyl)-amino]-3-[4-(5-methoxy-2-methyl-3-oxo-2,3-dihydro-pyridazin-4-yl)-phenyl]-propionic acid methyl ester; 2-methylpropyl(methyl)amine; In acetonitrile; at 23 ℃; for 19h;

With lithium hydroxide; In acetonitrile; at 23 ℃; for 9h;
DOI:10.1021/jm060031q

Reference yield:

: (S)-2-Amino-3-[4-(5-methoxy-2-methyl-3-oxo-2,3-dihydro-pyridazin-4-yl)-phenyl]-propionic acid; compound with trifluoro-acetic acid

: 862854-00-0
(S)-2-(3-Isobutyl-3-methyl-ureido)-3-[4-(5-methoxy-2-methyl-3-oxo-2,3-dihydro-pyridazin-4-yl)-phenyl]-propionic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: 66 percent / SOCl₂ / 2 h / Heating

2.1: 81 percent / 1 h / 23 °C

3.1: acetonitrile / 19 h / 23 °C

3.2: aq. lithium hydroxide / acetonitrile / 9 h / 23 °C

With thionyl chloride; In acetonitrile;
DOI:10.1021/jm060031q