625-43-4

Basic information

• Product Name: N-METHYLISOBUTYLAMINE
• Synonyms: N-Methyl-N-(2-methylpropyl)amine;N-METHYLISOBUTYLAMIN;N-MethylisobutylaMine, 98.0%(GC);N-Methylisobutylamine;1-Propanamine,N,2-dimethyl-;2-Methyl-1-(methylamino)propane;Isobutylmethylamine;n,2-dimethyl-1-propanamin
• CAS NO: 625-43-4
• Molecular Formula: C₅H₁₃N
• Molecular Weight: 87.16
• EINECS: 210-893-0
• Mol File: 625-43-4.mol
• Article Data: 10

Chemical Properties

• Melting Point: -75°C (estimate)
• Boiling Point: 78 °C
• Appearance: /Liquid
• Density: 0,73 g/cm3
• Vapor Pressure: 116mmHg at 25°C
• Refractive Index: 1.3950 to 1.3970
• PKA: 10.76±0.20(Predicted)
• Water Solubility: Miscible with water.
• CAS DataBase Reference: N-METHYLISOBUTYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: N-METHYLISOBUTYLAMINE(625-43-4)
• EPA Substance Registry System: N-METHYLISOBUTYLAMINE(625-43-4)

Safety Data

• Hazard Codes: Xn
• Statements: 11-34-52-41-37/38-22
• Safety Statements: 26-36/37/39-39
• RIDADR: 2733
• WGK Germany: 3
• TSCA: Yes
• HazardClass: 3
• PackingGroup: II
• Hazardous Substances Data: 625-43-4(Hazardous Substances Data)

Usage

Uses

N-Methylisobutylamine is used as an pharmaceutical intermediate.

InChI:InChI=1/C5H13N/c1-5(2)4-6-3/h5-6H,4H2,1-3H3/p+1

Upstream product

• 78-84-2 isobutyraldehyde 
• 74-89-5 methylamine 
• 33489-88-2 1,3,5-Tris(isobutyl)-hexahydro-1,3,5-triazin 
• 6898-70-0 N-isobutylidenemethylamine 
• 539-89-9 isobutyl-carbamic acid ethyl ester 
• 187737-37-7 propene 
• 6281-96-5 N-isobutylformamide 
• 34419-76-6 N-nitroso-N-methylisobutylamine 
• 64-19-7 acetic acid 
• 124-38-9 carbon dioxide 
• 124-40-3 dimethyl amine 
• 27845-49-4 benzylideneisobutylamine 
• 74-88-4 methyl iodide 

Downstream Products

• 81499-28-7 N-isobutyl-N-methyl-benzamide 
• 52317-78-9 3-(2,4-Dimethyl-phenyl)-1-isobutyl-1-methyl-thiourea 
• 52317-85-8 3-(4-Bromo-2-methyl-phenyl)-1-isobutyl-1-methyl-thiourea 
• 52479-23-9 1-methyl-1-isobutyl-3-(2-methyl-4-chlorophenyl)-thiourea 
• 52317-92-7 3-(4-Fluoro-2-methyl-phenyl)-1-isobutyl-1-methyl-thiourea 
• 64796-58-3 3-[1-(3-Chloro-phenyl)-1-methyl-ethyl]-1-isobutyl-1-methyl-urea 
• 64796-87-8 1-i-Butyl-3-(p-chloro-α,α-dimethylbenzyl)-1-methylurea 
• 64796-38-9 3-[1-(2-Chloro-phenyl)-1-methyl-ethyl]-1-isobutyl-1-methyl-urea 
• 701271-68-3 4-(6-{4-[(isobutyl-methyl-carbamoyl)-methyl]-phenyl}-pyridine-3-sulfonyl)-tetrahydro-pyran-4-carboxylic acid tert-butyl ester 
• 742099-24-7 5-bromo-2-[isobutyl(methyl)amino]benzaldehyde 
• 473547-42-1 [4-cyano-5-(isobutyl-methyl-amino)-2-nitro-phenyl]-carbamic acid tert-butyl ester 
• 473551-50-7 8-chloro-4-(3-{5-[(isobutyl-methyl-amino)-methyl]-[1,2,3]triazol-1-yl}-phenyl)-7-(isopropyl-methyl-amino)-1,3-dihydro-benzo[b][1,4]diazepin-2-one 
• 229004-73-3 N-(4-((N-isobutyl-N-methyl)aminomethyl)phenyl)-7-(4-methyl-phenyl)-2,3-dihydro-1-benzoxepine-4-carboxamide 
• 515164-50-8 N-(5-(3-(isobutyl-methyl-amino)phenoxy)-2-nitrophenyl)-N-methylcarbamic acid t-butyl ester 

Relevant articles and documents

Isolation and Characterization of Well-Defined Silica-Supported Azametallacyclopentane: A Key Intermediate in Catalytic Hydroaminoalkylation Reactions

Intermolecular catalytic hydroaminoalkylation of unactivated alkene occurs with silica-supported azazirconacyclopropane [≡Si-O-Zr(HNMe2)(η2-NMeCH2)(NMe2)]. Mechanistic studies were conducted using surface organometallic chemistry (SOMC) concepts to identify the key surface intermediates. The azametallacyclopentene intermediate {≡Si-O-Zr(HNMe2)[η2-NMeCH2CH(Me)CH2](NMe2)} was isolated after treating with 1-propylene and characterized by FT-IR spectroscopy, elemental analysis, 1H 13C HETCOR, DARR SS-NMR and DQ TQ SS-NMR. The regeneration of the catalyst was conducted by dimethylamine protonolysis to yield the pure amine.

SUBSTITUTED QUINAZOLINE DERIVATIVES AND THEIR USE AS INHIBITORS

The use of a compound of formula (I) 1 or a salt, ester or amide thereof; where X is O, or S, S(O) or S(O)2, or NR6 where R6 is hydrogen or C1-6 alkyl,; R5 is an optionally substituted 5-membered heteroaromatic ring, R1, R2 ,R3, R4 are independently selected from various specified moieties, in the preparation of a medicament for use in the inhibition of aurora 2 kinase. Certain compounds are novel and these, together with pharmaceutical compositions containing them are also described and claimed

ELECTROCHEMICAL REDUCTIVE AMINATION. II. AMINATION OF ALIPHATIC ALDEHYDES WITH PRIMARY AMINES

The formation of a secondary amine by the electrolysis of an aqueous solution containing an aldehyde and a primary amine was studied.The formation of the secondary amines passes through the intermediate stage of an aldimine.The highest yield of secondary amine is attained at a molar ratio of primary amine to aldehyde of 1.2:1.As electrode material lead, cadmium, zinc, and copper may be used.As supporting electrolyte a phosphate buffer with a pH close to the pKa of the primary amine is recommended.By the method developed 32 amines with various structures were synthesized.