2-Methoxybenzylamine

Base Information

• Chemical Name: 2-Methoxybenzylamine
• CAS No.: 6850-57-3
• Molecular Formula: C8H11NO
• Molecular Weight: 137.181
• Hs Code.: 29221980
• European Community (EC) Number: 229-941-7
• UNII: 2JK6T542T8
• DSSTox Substance ID: DTXSID60218629
• Nikkaji Number: J149.911D
• Wikidata: Q72489238
• Mol file: 6850-57-3.mol

Synonyms:2-Methoxybenzylamine;6850-57-3;(2-Methoxyphenyl)methanamine;o-Methoxybenzylamine;Benzenemethanamine, 2-methoxy-;1-(2-methoxyphenyl)methanamine;MFCD00008110;2-methoxy benzylamine;2JK6T542T8;EINECS 229-941-7;(2-methoxyphenyl)methylamine;2-methoxy-benzylamine;2-(Aminomethyl)anisole;2-methyoxybenzylamine;2-methoxybenzyl amine;2-methoxy benzyl amine;2-methoxy-benzyl-amine;2-Methoxy-benzyl amine;(2-methoxy-benzyl)amine;2-methoxybenzenemethanamine;2-methoxy-benzenemethanamine;2-Methoxybenzylamine, 98%;Oprea1_790414;SCHEMBL39970;(O-ANISYLMETHYL)AMINE;UNII-2JK6T542T8;(2-methoxyphenyl)-methyl-amine;(2-methoxyphenyl)methylammonium;SCHEMBL5270103;(2-Methoxyphenyl)methanamine #;2-METHOXYPHENYLMETHYLAMINE;DTXSID60218629;O-METHOXYBENZENEMETHANAMINE;{[2-(methoxy)phenyl]methyl}amine;BCP11246;1-[2-(Methyloxy)phenyl]methanamine;BBL027680;STL302615;AKOS000120423;CS-W011056;PS-5318;AM20041008;FT-0612829;M0869;EN300-18379;F14886;A836165;W-104666;Z57102476;F0798-0704;V6Q

Chemical Property of 2-Methoxybenzylamine

Chemical Property:

• Appearance/Colour: Colorless to light yellow liquid
• Vapor Pressure: 0.0712mmHg at 25°C
• Melting Point: 60 °C
• Refractive Index: n20/D 1.548(lit.)
• Boiling Point: 228.993 °C at 760 mmHg
• PKA: 9.15±0.10(Predicted)
• Flash Point: 100 °C
• PSA: 35.25000
• Density: 1..0±0.1 g/cm³
• LogP: 1.85420
• Storage Temp.: Store below +30°C.
• Sensitive.: Air Sensitive
• Water Solubility.: slightly soluble
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 137.084063974
• Heavy Atom Count: 10
• Complexity: 95.3

Purity/Quality:

97% ^*data from raw suppliers

2-Methoxybenzylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi,C
• Hazard Codes: C,Xi
• Statements: 34-37
• Safety Statements: 26-36/37/39-45-27

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC=C1CN
• Uses: 2-Methoxybenzylamine is a 2-methoxy derivative of benzylamine. 2-Methoxybenzylamine is one the the metabolites detected in urine after metabolism of dopamine analogues. 2-Methoxybenzylamine is used in the preparation of GABAA receptor ligands as analgesic agents. 2-Methoxybenzylamine was used in the preparation of 6-substituted purines.

Technology Process of 2-Methoxybenzylamine

There total 21 articles about 2-Methoxybenzylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

→ 2-methoxybenzylamine (6850-57-3)

Guidance literature:

With ammonia; hydrogen; In methanol; at 90 ℃; for 4h; under 15001.5 Torr; Autoclave;

Reference yield: 99.0%

2-methoxy-benzonitrile (6609-56-9) → 2-methoxybenzylamine (6850-57-3)

Guidance literature:

With ammonia; hydrogen; In water; isopropyl alcohol; at 100 ℃; for 24h; under 15001.5 Torr; Autoclave;

DOI:10.1002/chem.202001866

Reference yield: 95.0%

N-trityl-2-methoxybenzylamine → 2-methoxybenzylamine (6850-57-3)

Guidance literature:

With hydrogenchloride; In ethanol;

DOI:10.1016/S0040-4039(00)00270-7

upstream raw materials:

methanol

N-acetyl-2-methoxybenzylamine

2-methoxy-benzonitrile

α'-amino-2,2'-dimethoxy-bibenzyl-α-ol

Downstream raw materials:

(2-methoxy-benzyl)-urea

1-(isothiocyanatomethyl)-2-methoxybenzene

2-(2-methoxybenzyl)isoindoline-1,3-dione

N-acetyl-2-methoxybenzylamine