4-((2S)-4-((6-amino-3-pyridinyl)sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)-N-(cyclopropylmethyl)benzenesulfonamide

Base Information

Chemical Name:4-((2S)-4-((6-amino-3-pyridinyl)sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)-N-(cyclopropylmethyl)benzenesulfonamide
CAS No.:1572927-62-8
Molecular Formula:C₂₂H₂₇N₅O₄S₂
Molecular Weight:489.619
Hs Code.:

Synonyms:4-((2S)-4-((6-amino-3-pyridinyl)sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)-N-(cyclopropylmethyl)benzenesulfonamide

Suppliers and Price of 4-((2S)-4-((6-amino-3-pyridinyl)sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)-N-(cyclopropylmethyl)benzenesulfonamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 4-((2S)-4-((6-amino-3-pyridinyl)sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)-N-(cyclopropylmethyl)benzenesulfonamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-((2S)-4-((6-amino-3-pyridinyl)sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)-N-(cyclopropylmethyl)benzenesulfonamide

There total 15 articles about 4-((2S)-4-((6-amino-3-pyridinyl)sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)-N-(cyclopropylmethyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1572928-29-0
tert-butyl (5-(((3S)-4-(4-((cyclopropylmethyl)sulfamoyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate

: 1572927-62-8
4-((2S)-4-((6-amino-3-pyridinyl)sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)-N-(cyclopropylmethyl)benzenesulfonamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃;
DOI:10.1021/jm5000497

Reference yield:

: 1572928-27-8
4-((2S)-4-benzyl-2-(1-propyn-1-yl)-1-piperazinyl)-N-(cyclopropylmethyl)benzenesulfonamide

: 1572927-62-8
4-((2S)-4-((6-amino-3-pyridinyl)sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)-N-(cyclopropylmethyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate; carbonochloridic acid 1-chloro-ethyl ester / dichloromethane / 12 h / 0 - 20 °C

1.2: 2 h / 80 °C

2.1: pyridine / dichloromethane / 1 h / 20 °C / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C

With pyridine; carbonochloridic acid 1-chloro-ethyl ester; potassium carbonate; trifluoroacetic acid; In dichloromethane;

Reference yield:

: 1450621-78-9
(3S)-1-benzyl-3-(2-propyn-1-yl)-2,5-piperazinedione

: 1572927-62-8
4-((2S)-4-((6-amino-3-pyridinyl)sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)-N-(cyclopropylmethyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 12 h / 80 °C

2.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 20 °C

3.1: chloro(2-dicyclohexylphosphino-2′,6′-di-i-propoxy-1,1′-biphenyl)(2′-amino-1,1′-biphenyl-2-yl)-palladium(II); sodium t-butanolate; ruphos / 1,4-dioxane / 4 h / 20 - 110 °C / Inert atmosphere

4.1: potassium carbonate; carbonochloridic acid 1-chloro-ethyl ester / dichloromethane / 12 h / 0 - 20 °C

4.2: 2 h / 80 °C

5.1: pyridine / dichloromethane / 1 h / 20 °C / Inert atmosphere

6.1: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C

With pyridine; lithium aluminium tetrahydride; carbonochloridic acid 1-chloro-ethyl ester; chloro(2-dicyclohexylphosphino-2′,6′-di-i-propoxy-1,1′-biphenyl)(2′-amino-1,1′-biphenyl-2-yl)-palladium(II); potassium tert-butylate; potassium carbonate; trifluoroacetic acid; sodium t-butanolate; ruphos; In tetrahydrofuran; 1,4-dioxane; dichloromethane;