N-(cyclopropylmethyl)-4-((2S)-2-(1-propyn-1-yl)-1-piperazinyl)benzenesulfonamide

Base Information

Chemical Name:N-(cyclopropylmethyl)-4-((2S)-2-(1-propyn-1-yl)-1-piperazinyl)benzenesulfonamide
CAS No.:1572928-28-9
Molecular Formula:C₁₇H₂₃N₃O₂S
Molecular Weight:333.455
Hs Code.:

Synonyms:N-(cyclopropylmethyl)-4-((2S)-2-(1-propyn-1-yl)-1-piperazinyl)benzenesulfonamide

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Chemical Property of N-(cyclopropylmethyl)-4-((2S)-2-(1-propyn-1-yl)-1-piperazinyl)benzenesulfonamide

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Technology Process of N-(cyclopropylmethyl)-4-((2S)-2-(1-propyn-1-yl)-1-piperazinyl)benzenesulfonamide

There total 10 articles about N-(cyclopropylmethyl)-4-((2S)-2-(1-propyn-1-yl)-1-piperazinyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1572928-27-8
4-((2S)-4-benzyl-2-(1-propyn-1-yl)-1-piperazinyl)-N-(cyclopropylmethyl)benzenesulfonamide

: 1572928-28-9
N-(cyclopropylmethyl)-4-((2S)-2-(1-propyn-1-yl)-1-piperazinyl)benzenesulfonamide

Guidance literature:: 4-((2S)-4-benzyl-2-(1-propyn-1-yl)-1-piperazinyl)-N-(cyclopropylmethyl)benzenesulfonamide; With carbonochloridic acid 1-chloro-ethyl ester; potassium carbonate; In dichloromethane; at 0 - 20 ℃; for 12h;

With methanol; In dichloromethane; at 80 ℃; for 2h;

Reference yield:

: 1450621-78-9
(3S)-1-benzyl-3-(2-propyn-1-yl)-2,5-piperazinedione

: 1572928-28-9
N-(cyclopropylmethyl)-4-((2S)-2-(1-propyn-1-yl)-1-piperazinyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 12 h / 80 °C

2.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 20 °C

3.1: chloro(2-dicyclohexylphosphino-2′,6′-di-i-propoxy-1,1′-biphenyl)(2′-amino-1,1′-biphenyl-2-yl)-palladium(II); sodium t-butanolate; ruphos / 1,4-dioxane / 4 h / 20 - 110 °C / Inert atmosphere

4.1: potassium carbonate; carbonochloridic acid 1-chloro-ethyl ester / dichloromethane / 12 h / 0 - 20 °C

4.2: 2 h / 80 °C

With lithium aluminium tetrahydride; carbonochloridic acid 1-chloro-ethyl ester; chloro(2-dicyclohexylphosphino-2′,6′-di-i-propoxy-1,1′-biphenyl)(2′-amino-1,1′-biphenyl-2-yl)-palladium(II); potassium tert-butylate; potassium carbonate; sodium t-butanolate; ruphos; In tetrahydrofuran; 1,4-dioxane; dichloromethane;

Reference yield:

: 1450621-79-0
(3S)-1-benzyl-3-(2-propyn-1-yl)-piperazine

: 1572928-28-9
N-(cyclopropylmethyl)-4-((2S)-2-(1-propyn-1-yl)-1-piperazinyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 20 °C

2.1: chloro(2-dicyclohexylphosphino-2′,6′-di-i-propoxy-1,1′-biphenyl)(2′-amino-1,1′-biphenyl-2-yl)-palladium(II); sodium t-butanolate; ruphos / 1,4-dioxane / 4 h / 20 - 110 °C / Inert atmosphere

3.1: potassium carbonate; carbonochloridic acid 1-chloro-ethyl ester / dichloromethane / 12 h / 0 - 20 °C

3.2: 2 h / 80 °C

With carbonochloridic acid 1-chloro-ethyl ester; chloro(2-dicyclohexylphosphino-2′,6′-di-i-propoxy-1,1′-biphenyl)(2′-amino-1,1′-biphenyl-2-yl)-palladium(II); potassium tert-butylate; potassium carbonate; sodium t-butanolate; ruphos; In tetrahydrofuran; 1,4-dioxane; dichloromethane;