2-[9-chloro-6-(3-hydroxy-3-methylbutyl)-1H-phenanthro[9,10-d]imidazol-2-yl]isophthalonitrile

Base Information

Chemical Name:2-[9-chloro-6-(3-hydroxy-3-methylbutyl)-1H-phenanthro[9,10-d]imidazol-2-yl]isophthalonitrile
CAS No.:892550-35-5
Molecular Formula:C₂₈H₂₁ClN₄O
Molecular Weight:464.954
Hs Code.:

Synonyms:2-[9-chloro-6-(3-hydroxy-3-methylbutyl)-1H-phenanthro[9,10-d]imidazol-2-yl]isophthalonitrile

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Chemical Property of 2-[9-chloro-6-(3-hydroxy-3-methylbutyl)-1H-phenanthro[9,10-d]imidazol-2-yl]isophthalonitrile

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Technology Process of 2-[9-chloro-6-(3-hydroxy-3-methylbutyl)-1H-phenanthro[9,10-d]imidazol-2-yl]isophthalonitrile

There total 15 articles about 2-[9-chloro-6-(3-hydroxy-3-methylbutyl)-1H-phenanthro[9,10-d]imidazol-2-yl]isophthalonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 892549-54-1
2-[9-chloro-6-(3-hydroxy-3-methylbut-1-yn-1-yl)-1H-phenanthro[9,10-d]imidazol-2-yl]isophthalonitrile

: 892550-35-5
2-[9-chloro-6-(3-hydroxy-3-methylbutyl)-1H-phenanthro[9,10-d]imidazol-2-yl]isophthalonitrile

Guidance literature:: 2-methyl-3-buten-2-ol; With 9-bora-bicyclo[3.3.1]nonane; In tetrahydrofuran; at 20 ℃;

2-[9-chloro-6-(3-hydroxy-3-methylbut-1-yn-1-yl)-1H-phenanthro[9,10-d]imidazol-2-yl]isophthalonitrile; With triphenyl-arsane; caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; water; N,N-dimethyl-formamide; for 120.083h;

Reference yield:

: 892550-48-0
(2E)-3-(2-amino-4-chlorophenyl)-2-(4-bromophenyl)acrylic acid

: 892550-35-5
2-[9-chloro-6-(3-hydroxy-3-methylbutyl)-1H-phenanthro[9,10-d]imidazol-2-yl]isophthalonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: sulfuric acid / water / 0 °C

1.2: 0.17 h / 0 °C

2.1: chromium(VI) oxide / acetic acid / 3 h / 110 °C

3.1: ammonium acetate / acetic acid / 120 °C

4.1: N,N-dimethyl-formamide / 85 °C

5.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 20 °C

5.2: 120 h / 20 °C

With chromium(VI) oxide; sulfuric acid; ammonium acetate; 9-bora-bicyclo[3.3.1]nonane; In tetrahydrofuran; water; acetic acid; N,N-dimethyl-formamide;

Reference yield:

: 937053-63-9
6-chloro-phenanthren-9-ol

: 892550-35-5
2-[9-chloro-6-(3-hydroxy-3-methylbutyl)-1H-phenanthro[9,10-d]imidazol-2-yl]isophthalonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: bromine / 1,2-dimethoxyethane / 4.33 h / 15 - 45 °C

1.2: 5 h / 50 - 55 °C

2.1: ammonium acetate / acetic acid / 120 °C

3.1: N,N-dimethyl-formamide / 85 °C

4.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 20 °C

4.2: 120 h / 20 °C

With ammonium acetate; bromine; 9-bora-bicyclo[3.3.1]nonane; In tetrahydrofuran; 1,2-dimethoxyethane; acetic acid; N,N-dimethyl-formamide;