7-(3-nitrophenyl)-5,7-dihydro-6H-10-thia-7a,11-diaza-cyclopenta[b]phenanthren-8-one

Base Information

• Chemical Name: 7-(3-nitrophenyl)-5,7-dihydro-6H-10-thia-7a,11-diaza-cyclopenta[b]phenanthren-8-one
• CAS No.: 335206-61-6
• Molecular Formula: C₂₀H₁₅N₃O₃S
• Molecular Weight: 377.423
• Mol file: 335206-61-6.mol

Synonyms:7-(3-nitrophenyl)-5,7-dihydro-6H-10-thia-7a,11-diaza-cyclopenta[b]phenanthren-8-one

Chemical Property of 7-(3-nitrophenyl)-5,7-dihydro-6H-10-thia-7a,11-diaza-cyclopenta[b]phenanthren-8-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-(3-nitrophenyl)-5,7-dihydro-6H-10-thia-7a,11-diaza-cyclopenta[b]phenanthren-8-one

There total 5 articles about 7-(3-nitrophenyl)-5,7-dihydro-6H-10-thia-7a,11-diaza-cyclopenta[b]phenanthren-8-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.8%

4-(3-nitrophenyl)-3,4,5,6-tetrahydro-1H-benzo[h]quinazolin-2-thione (335206-60-5) + chloroacetic acid (79-11-8) → 7-(3-nitrophenyl)-5,7-dihydro-6H-10-thia-7a,11-diaza-cyclopenta[b]phenanthren-8-one (335206-61-6)

Guidance literature:

With sodium acetate; acetic anhydride; acetic acid; for 2h; Reflux;

DOI:10.1021/jm901004c

Reference yield: 65.0%

4-(3-nitrophenyl)-3,4,5,6-tetrahydro-1H-benzo[h]quinazolin-2-thione (335206-60-5) + N-chloroacetyl-aniline (587-65-5) → 7-(3-nitrophenyl)-5,7-dihydro-6H-10-thia-7a,11-diaza-cyclopenta[b]phenanthren-8-one (335206-61-6)

Guidance literature:

With acetic acid; for 6h; Reagent/catalyst; Reflux;

DOI:10.1016/j.tetlet.2013.11.001

Reference yield: 63.0%

4-(3-nitrophenyl)-3,4,5,6-tetrahydro-1H-benzo[h]quinazolin-2-thione (335206-60-5) + N-benzothiazol-2-yl-2-chloroacetamide (3028-02-2) → 7-(3-nitrophenyl)-5,7-dihydro-6H-10-thia-7a,11-diaza-cyclopenta[b]phenanthren-8-one (335206-61-6)

Guidance literature:

With triethylamine; In 1,4-dioxane; for 5h; Reagent/catalyst; Reflux;

DOI:10.1016/j.tetlet.2013.11.001

upstream raw materials:

4-(3-nitrophenyl)-3,4,5,6-tetrahydro-1H-benzo[h]quinazolin-2-thione

chloroacetic acid

N-chloroacetyl-aniline

N-benzothiazol-2-yl-2-chloroacetamide

Downstream raw materials:

10-((1H-indol-3-yl)methylene)-7-(3-nitrophenyl)-7,10-dihydro-5H-benzo[h]thiazolo[2,3-b]quinazolin-9(6H)-one

(Z)-3-(5-((7-(3-nitrophenyl)-9-oxo-5H-benzo[h]thiazolo[2,3-b]quinazolin-10(6H,7H,9H)-ylidene)methyl)furan-2-yl)benzoic acid