4-(3-nitrophenyl)-3,4,5,6-tetrahydro-1H-benzo[h]quinazolin-2-thione

Base Information

• Chemical Name: 4-(3-nitrophenyl)-3,4,5,6-tetrahydro-1H-benzo[h]quinazolin-2-thione
• CAS No.: 335206-60-5
• Molecular Formula: C₁₈H₁₅N₃O₂S
• Molecular Weight: 337.402
• Mol file: 335206-60-5.mol

Synonyms:4-(3-nitrophenyl)-3,4,5,6-tetrahydro-1H-benzo[h]quinazolin-2-thione

Chemical Property of 4-(3-nitrophenyl)-3,4,5,6-tetrahydro-1H-benzo[h]quinazolin-2-thione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(3-nitrophenyl)-3,4,5,6-tetrahydro-1H-benzo[h]quinazolin-2-thione

There total 2 articles about 4-(3-nitrophenyl)-3,4,5,6-tetrahydro-1H-benzo[h]quinazolin-2-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-nitro-benzaldehyde (99-61-6) + thiourea (17356-08-0) + 3,4-dihydronaphthalene-1(2H)-one (529-34-0) → 4-(3-nitrophenyl)-3,4,5,6-tetrahydro-1H-benzo[h]quinazolin-2-thione (335206-60-5)

Guidance literature:

With poly(4-vinylpyridinium)hydrogen sulfate; In neat (no solvent); at 120 ℃;

DOI:10.1016/j.tetlet.2013.11.001

Reference yield:

2-(3-nitrobenzylidene)-3,4-dihydronaphthalen-1(2H)one (66045-86-1) + thiourea (17356-08-0) → 4-(3-nitrophenyl)-3,4,5,6-tetrahydro-1H-benzo[h]quinazolin-2-thione (335206-60-5)

Guidance literature:

With potassium hydroxide; In ethanol; for 5h; Reflux;

DOI:10.1021/jm901004c

Reference yield: 82.0%

4-(3-nitrophenyl)-3,4,5,6-tetrahydro-1H-benzo[h]quinazolin-2-thione (335206-60-5) + chloroacetic acid (79-11-8) → C20H17N3O3S (1440807-86-2)

Guidance literature:

In neat (no solvent); for 0.333333h; regioselective reaction; Heating;

DOI:10.3762/bjoc.9.78

upstream raw materials:

2-(3-nitrobenzylidene)-3,4-dihydronaphthalen-1(2H)one

thiourea

3-nitro-benzaldehyde

3,4-dihydronaphthalene-1(2H)-one

Downstream raw materials:

7-(3-nitrophenyl)-5,7-dihydro-6H-10-thia-7a,11-diaza-cyclopenta[b]phenanthren-8-one

C₂₀H₁₇N₃O₃S

10-((1H-indol-3-yl)methylene)-7-(3-nitrophenyl)-7,10-dihydro-5H-benzo[h]thiazolo[2,3-b]quinazolin-9(6H)-one