N-{1-[3-(2-ethoxy-phenyl)-5-oxo-4,5-dihydro-[1,2,4]triazin-6-yl]ethyl}acetamide

Base Information

Chemical Name:N-{1-[3-(2-ethoxy-phenyl)-5-oxo-4,5-dihydro-[1,2,4]triazin-6-yl]ethyl}acetamide
CAS No.:1417529-59-9
Molecular Formula:C₁₅H₁₈N₄O₃
Molecular Weight:302.333
Hs Code.:

Synonyms:N-{1-[3-(2-ethoxy-phenyl)-5-oxo-4,5-dihydro-[1,2,4]triazin-6-yl]ethyl}acetamide

Suppliers and Price of N-{1-[3-(2-ethoxy-phenyl)-5-oxo-4,5-dihydro-[1,2,4]triazin-6-yl]ethyl}acetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 3 raw suppliers

Chemical Property of N-{1-[3-(2-ethoxy-phenyl)-5-oxo-4,5-dihydro-[1,2,4]triazin-6-yl]ethyl}acetamide

Chemical Property:

Purity/Quality:: 95%+HPLC ^*data from raw suppliers

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Technology Process of N-{1-[3-(2-ethoxy-phenyl)-5-oxo-4,5-dihydro-[1,2,4]triazin-6-yl]ethyl}acetamide

There total 3 articles about N-{1-[3-(2-ethoxy-phenyl)-5-oxo-4,5-dihydro-[1,2,4]triazin-6-yl]ethyl}acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1417529-56-6
C₁₃H₁₆N₄O₂

: 75-36-5
acetyl chloride

: 1417529-59-9
N-{1-[3-(2-ethoxy-phenyl)-5-oxo-4,5-dihydro-[1,2,4]triazin-6-yl]ethyl}acetamide

Guidance literature:: C₁₃H₁₆N₄O₂; With tertiary amine; In dichloromethane; for 0.0833333h; Cooling;

acetyl chloride; In dichloromethane; at 0 - 20 ℃; for 1.16667h;
DOI:10.1016/j.tet.2012.11.037

Reference yield:

: 1417529-52-2
3-(2-ethoxyphenyl)-6-ethyl-4H-[1,2,4]triazin-5-one

: 1417529-59-9
N-{1-[3-(2-ethoxy-phenyl)-5-oxo-4,5-dihydro-[1,2,4]triazin-6-yl]ethyl}acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 14 h / Reflux; Inert atmosphere

2.1: ammonia / tetrahydrofuran / 20 °C

3.1: tertiary amine / dichloromethane / 0.08 h / Cooling

3.2: 1.17 h / 0 - 20 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); ammonia; In tetrahydrofuran; tetrachloromethane; dichloromethane;
DOI:10.1016/j.tet.2012.11.037

Reference yield:

: 1417529-54-4
6-(1-bromoethyl)-3-(2-ethoxyphenyl)-4H-[1,2,4]triazin-5-one

: 1417529-59-9
N-{1-[3-(2-ethoxy-phenyl)-5-oxo-4,5-dihydro-[1,2,4]triazin-6-yl]ethyl}acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: ammonia / tetrahydrofuran / 20 °C

2.1: tertiary amine / dichloromethane / 0.08 h / Cooling

2.2: 1.17 h / 0 - 20 °C

With ammonia; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tet.2012.11.037