phenyl 3-(2-hydroxyphenyl)-5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazole-1-carboxylate

Base Information

Chemical Name:phenyl 3-(2-hydroxyphenyl)-5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazole-1-carboxylate
CAS No.:1491063-56-9
Molecular Formula:C₂₂H₁₇ClN₂O₃
Molecular Weight:392.842
Hs Code.:

Synonyms:phenyl 3-(2-hydroxyphenyl)-5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazole-1-carboxylate

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Chemical Property of phenyl 3-(2-hydroxyphenyl)-5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazole-1-carboxylate

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Technology Process of phenyl 3-(2-hydroxyphenyl)-5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazole-1-carboxylate

There total 4 articles about phenyl 3-(2-hydroxyphenyl)-5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1885-14-9
phenyl chloroformate

: 65840-95-1
3-(2′-hydroxyphenyl)-5-(4-chlorophenyl)pyrazoline

: 1491063-56-9
phenyl 3-(2-hydroxyphenyl)-5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazole-1-carboxylate

Guidance literature:: With potassium carbonate; In methanol; at 10 ℃; for 0.5h;
DOI:10.1016/j.ejmech.2013.09.010

Reference yield:

: 118-93-4,104809-67-8
o-hydroxyacetophenone

: 1491063-56-9
phenyl 3-(2-hydroxyphenyl)-5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazole-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / methanol / 72 h / 20 °C

2: hydrazine / methanol / Reflux

3: potassium carbonate / methanol / 0.5 h / 10 °C

With potassium carbonate; sodium hydroxide; hydrazine; In methanol; 1: |Claisen-Schmidt Condensation;
DOI:10.1016/j.ejmech.2013.09.010

Reference yield:

: 104-88-1
4-chlorobenzaldehyde

: 1491063-56-9
phenyl 3-(2-hydroxyphenyl)-5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazole-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / methanol / 72 h / 20 °C

2: hydrazine / methanol / Reflux

3: potassium carbonate / methanol / 0.5 h / 10 °C

With potassium carbonate; sodium hydroxide; hydrazine; In methanol; 1: |Claisen-Schmidt Condensation;
DOI:10.1016/j.ejmech.2013.09.010