2-p-tolyl-6-(trifluoromethyl)-4,5-dihydropyridazin-3(2H)-one

Base Information

• Chemical Name: 2-p-tolyl-6-(trifluoromethyl)-4,5-dihydropyridazin-3(2H)-one
• CAS No.: 1161004-75-6
• Molecular Formula: C₁₂H₁₁F₃N₂O
• Molecular Weight: 256.227
• Mol file: 1161004-75-6.mol

Synonyms:2-p-tolyl-6-(trifluoromethyl)-4,5-dihydropyridazin-3(2H)-one

Chemical Property of 2-p-tolyl-6-(trifluoromethyl)-4,5-dihydropyridazin-3(2H)-one

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2-p-tolyl-6-(trifluoromethyl)-4,5-dihydropyridazin-3(2H)-one

There total 1 articles about 2-p-tolyl-6-(trifluoromethyl)-4,5-dihydropyridazin-3(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

4-trifluoromethyl-4-oxobutyric acid ethyl ester (70961-05-6) + N-4-methylphenylhydrazine (539-44-6) → 2-p-tolyl-6-(trifluoromethyl)-4,5-dihydropyridazin-3(2H)-one (1161004-75-6) + C14H17F3N2O2

Guidance literature:

With toluene-4-sulfonic acid; In toluene; for 24h; Inert atmosphere; Reflux;

DOI:10.1016/j.tet.2009.03.029

Reference yield: 95.0%

2-p-tolyl-6-(trifluoromethyl)-4,5-dihydropyridazin-3(2H)-one (1161004-75-6) → C12H13F3N2O

Guidance literature:

With (S)-((4,4’-bi-1,3-benzodioxole)-5,5’-diyl)bis(diphenylphosphine); palladium(II) trifluoroacetate; hydrogen; trifluoroacetic acid; at 80 ℃; for 48h; under 51716.2 Torr;

DOI:10.1021/acscatal.5b01641

upstream raw materials:

4-trifluoromethyl-4-oxobutyric acid ethyl ester

N-4-methylphenylhydrazine