4-Nitro-benzoic acid (2R,3R)-8-chloro-5-(2-dimethylamino-ethyl)-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester

Base Information

Chemical Name:4-Nitro-benzoic acid (2R,3R)-8-chloro-5-(2-dimethylamino-ethyl)-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester
CAS No.:122666-34-6
Molecular Formula:C₂₇H₂₆ClN₃O₆S
Molecular Weight:556.039
Hs Code.:

Synonyms:4-Nitro-benzoic acid (2R,3R)-8-chloro-5-(2-dimethylamino-ethyl)-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester

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Chemical Property of 4-Nitro-benzoic acid (2R,3R)-8-chloro-5-(2-dimethylamino-ethyl)-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester

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Technology Process of 4-Nitro-benzoic acid (2R,3R)-8-chloro-5-(2-dimethylamino-ethyl)-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester

There total 10 articles about 4-Nitro-benzoic acid (2R,3R)-8-chloro-5-(2-dimethylamino-ethyl)-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.2%

: 105487-93-2
(2RS,3RS)-8-chloro-5-<2-(dimethylamino)ethyl>-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one

: 122666-34-6
4-Nitro-benzoic acid (2R,3R)-8-chloro-5-(2-dimethylamino-ethyl)-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester

Guidance literature:: With pyridine; for 3h; Ambient temperature;
DOI:10.1021/jm00106a032

Reference yield:

: 23474-98-8
2-amino-5-chlorobenzenethiol

: 122666-34-6
4-Nitro-benzoic acid (2R,3R)-8-chloro-5-(2-dimethylamino-ethyl)-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 60.5 percent / toluene / 24 h / 80 °C

2: 97.9 percent / 5percent aq. NaOH / ethanol / 3 h / Ambient temperature

3: 80.3 percent / xylene / 24 h / Heating

4: 96percent KOH / dimethylsulfoxide / 22 h / Ambient temperature

5: 96.2 percent / pyridine / 3 h / Ambient temperature

With pyridine; potassium hydroxide; sodium hydroxide; In ethanol; dimethyl sulfoxide; toluene; xylene;
DOI:10.1021/jm00106a032

Reference yield:

: 96125-49-4
methyl trans-3-(4-methoxyphenyl)glycidate

: 122666-34-6
4-Nitro-benzoic acid (2R,3R)-8-chloro-5-(2-dimethylamino-ethyl)-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 60.5 percent / toluene / 24 h / 80 °C

2: 97.9 percent / 5percent aq. NaOH / ethanol / 3 h / Ambient temperature

3: 80.3 percent / xylene / 24 h / Heating

4: 96percent KOH / dimethylsulfoxide / 22 h / Ambient temperature

5: 96.2 percent / pyridine / 3 h / Ambient temperature

With pyridine; potassium hydroxide; sodium hydroxide; In ethanol; dimethyl sulfoxide; toluene; xylene;
DOI:10.1021/jm00106a032