tert-butyl [3-[(2-chloro-5-fluoro-phenyl)methylamino]-6-methyl-2-oxo-4-thioxo-3,4-dihydro-2H-pyrimidin-1-yl]acetic acid

Base Information

Chemical Name:tert-butyl [3-[(2-chloro-5-fluoro-phenyl)methylamino]-6-methyl-2-oxo-4-thioxo-3,4-dihydro-2H-pyrimidin-1-yl]acetic acid
CAS No.:917391-36-7
Molecular Formula:C₁₈H₂₁ClFN₃O₃S
Molecular Weight:413.9
Hs Code.:

Synonyms:tert-butyl [3-[(2-chloro-5-fluoro-phenyl)methylamino]-6-methyl-2-oxo-4-thioxo-3,4-dihydro-2H-pyrimidin-1-yl]acetic acid

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Chemical Property of tert-butyl [3-[(2-chloro-5-fluoro-phenyl)methylamino]-6-methyl-2-oxo-4-thioxo-3,4-dihydro-2H-pyrimidin-1-yl]acetic acid

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Technology Process of tert-butyl [3-[(2-chloro-5-fluoro-phenyl)methylamino]-6-methyl-2-oxo-4-thioxo-3,4-dihydro-2H-pyrimidin-1-yl]acetic acid

There total 6 articles about tert-butyl [3-[(2-chloro-5-fluoro-phenyl)methylamino]-6-methyl-2-oxo-4-thioxo-3,4-dihydro-2H-pyrimidin-1-yl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 917391-33-4
tert-butyl [3-[2-chloro-5-fluoro-benzylamino]-6-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]acetate

: 917391-36-7
tert-butyl [3-[(2-chloro-5-fluoro-phenyl)methylamino]-6-methyl-2-oxo-4-thioxo-3,4-dihydro-2H-pyrimidin-1-yl]acetic acid

Guidance literature:: With Lawessons reagent; pyridine; Heating / reflux;

Reference yield:

: 917391-31-2
tert-butyl (6-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetate

: 917391-36-7
tert-butyl [3-[(2-chloro-5-fluoro-phenyl)methylamino]-6-methyl-2-oxo-4-thioxo-3,4-dihydro-2H-pyrimidin-1-yl]acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydride / N,N-dimethyl-formamide / 0.5 h

2: sodium hydroxide; water

3: acetic acid / methanol / 40 °C

4: sodium cyanoborohydride; acetic acid / methanol / 20 °C

5: Lawessons reagent; pyridine / Heating / reflux

With Lawessons reagent; pyridine; sodium hydroxide; water; sodium hydride; sodium cyanoborohydride; acetic acid; In methanol; N,N-dimethyl-formamide;

Reference yield:

: 917391-30-1
tert-butyl (3-amino-6-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetate

: 917391-36-7
tert-butyl [3-[(2-chloro-5-fluoro-phenyl)methylamino]-6-methyl-2-oxo-4-thioxo-3,4-dihydro-2H-pyrimidin-1-yl]acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid / methanol / 40 °C

2: sodium cyanoborohydride; acetic acid / methanol / 20 °C

3: Lawessons reagent; pyridine / Heating / reflux

With Lawessons reagent; pyridine; sodium cyanoborohydride; acetic acid; In methanol;