tert-butyl [3-[2-chloro-5-fluoro-benzylamino]-6-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]acetate

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Chemical Name:tert-butyl [3-[2-chloro-5-fluoro-benzylamino]-6-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]acetate
CAS No.:917391-33-4
Molecular Formula:C₁₈H₂₁ClFN₃O₄
Molecular Weight:397.834
Hs Code.:

Synonyms:tert-butyl [3-[2-chloro-5-fluoro-benzylamino]-6-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]acetate

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Chemical Property of tert-butyl [3-[2-chloro-5-fluoro-benzylamino]-6-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]acetate

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Technology Process of tert-butyl [3-[2-chloro-5-fluoro-benzylamino]-6-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]acetate

There total 5 articles about tert-butyl [3-[2-chloro-5-fluoro-benzylamino]-6-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.5%

: 917391-34-5
tert-butyl [3-{[(1E)-(2-chloro-5-fluoro-phenyl)methylene]amino}-6-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]acetate

: 917391-33-4
tert-butyl [3-[2-chloro-5-fluoro-benzylamino]-6-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]acetate

Guidance literature:: With sodium cyanoborohydride; acetic acid; In methanol; at 20 ℃;

Reference yield:

: 917391-31-2
tert-butyl (6-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetate

: 917391-33-4
tert-butyl [3-[2-chloro-5-fluoro-benzylamino]-6-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]acetate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydride / N,N-dimethyl-formamide / 0.5 h

2: sodium hydroxide; water

3: acetic acid / methanol / 40 °C

4: sodium cyanoborohydride; acetic acid / methanol / 20 °C

With sodium hydroxide; water; sodium hydride; sodium cyanoborohydride; acetic acid; In methanol; N,N-dimethyl-formamide;

Reference yield:

: 917391-30-1
tert-butyl (3-amino-6-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetate

: 917391-33-4
tert-butyl [3-[2-chloro-5-fluoro-benzylamino]-6-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]acetate

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid / methanol / 40 °C

2: sodium cyanoborohydride; acetic acid / methanol / 20 °C

With sodium cyanoborohydride; acetic acid; In methanol;