Technology Process of C23H17ClFN5O2
There total 5 articles about C23H17ClFN5O2 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
4-methoxy-3-[[4-(3-pyridyl)-2-pyrimidinyl]amino]benzoic acid;
With
4-methyl-morpholine; isobutyl chloroformate;
In
dichloromethane;
at 0 ℃;
for 0.5h;
Inert atmosphere;
3-chloro-4-fluorophenylamine;
With
isobutyl chloroformate;
In
dichloromethane;
at 20 ℃;
Inert atmosphere;
Cooling with ice;
DOI:10.1016/j.bmc.2013.02.036
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sulfuric acid / 12 h / 0 °C / Inert atmosphere; Reflux
2.1: hydrogenchloride / ethanol; water / 15 h / Reflux
2.2: 1 h / 0 °C
3.1: sodium hydroxide / butan-1-ol / 48 h / Reflux
4.1: sodium hydroxide / ethanol; water / 45 - 50 °C
5.1: 4-methyl-morpholine; isobutyl chloroformate / dichloromethane / 0.5 h / 0 °C / Inert atmosphere
5.2: 20 °C / Inert atmosphere; Cooling with ice
With
4-methyl-morpholine; hydrogenchloride; sulfuric acid; sodium hydroxide; isobutyl chloroformate;
In
ethanol; dichloromethane; water; butan-1-ol;
DOI:10.1016/j.bmc.2013.02.036
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: hydrogenchloride / ethanol; water / 15 h / Reflux
1.2: 1 h / 0 °C
2.1: sodium hydroxide / butan-1-ol / 48 h / Reflux
3.1: sodium hydroxide / ethanol; water / 45 - 50 °C
4.1: 4-methyl-morpholine; isobutyl chloroformate / dichloromethane / 0.5 h / 0 °C / Inert atmosphere
4.2: 20 °C / Inert atmosphere; Cooling with ice
With
4-methyl-morpholine; hydrogenchloride; sodium hydroxide; isobutyl chloroformate;
In
ethanol; dichloromethane; water; butan-1-ol;
DOI:10.1016/j.bmc.2013.02.036
