ETHYL 3-AMINO-4-METHOXYBENZOATE

Base Information

• Chemical Name: ETHYL 3-AMINO-4-METHOXYBENZOATE
• CAS No.: 16357-44-1
• Molecular Formula: C10H13NO3
• Molecular Weight: 195.218
• Hs Code.: 2922509090
• Mol file: 16357-44-1.mol

Synonyms:p-Anisicacid, 3-amino-, ethyl ester (8CI);Ethyl 3-amino-p-anisate;Ethyl 3-amino-4-methoxybenzoate;

Chemical Property of ETHYL 3-AMINO-4-METHOXYBENZOATE

Chemical Property:

• Boiling Point: 337.981 °C at 760 mmHg
• Flash Point: 167.247 °C
• PSA: 61.55000
• Density: 1.148 g/cm³
• LogP: 2.03530

Purity/Quality:

99% ^*data from raw suppliers

Ethyl 3-amino-4-methoxybenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ETHYL 3-AMINO-4-METHOXYBENZOATE

There total 3 articles about ETHYL 3-AMINO-4-METHOXYBENZOATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

ethanol (64-17-5) + 3-amino-4-methoxybenzoic acid (2840-26-8) → 3-amino-4-methoxy-benzoic acid ethyl ester (16357-44-1)

Guidance literature:

With sulfuric acid; at 0 ℃; for 12h; Inert atmosphere; Reflux;

DOI:10.1016/j.bmc.2013.02.036

Reference yield: 81.0%

ethyl 4-methoxy-3-nitrobenzoate (16357-47-4) → 3-amino-4-methoxy-benzoic acid ethyl ester (16357-44-1)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; for 168h; under 760.051 Torr; Darkness;

DOI:10.1002/ejoc.201000086

Reference yield:

→ 3-amino-4-methoxy-benzoic acid ethyl ester (16357-44-1)

Guidance literature:

Nitroverb. (IIIe, R=OEt), H2/PtO2;

DOI:10.1002/jsfa.2740180810

upstream raw materials:

ethyl 4-methoxy-3-nitrobenzoate

ethanol

3-amino-4-methoxybenzoic acid

Downstream raw materials:

4-methoxy-3-[[4-(3-pyridyl)-2-pyrimidinyl]amino]benzoic acid ethyl ester

4-methoxy-3-[[4-(3-pyridyl)-2-pyrimidinyl]amino]benzoic acid

C₂₃H₁₇ClFN₅O₂

C₂₄H₁₈F₃N₅O₂

Refernces

• 1、 Bhuiyan, M. Delower H.,Zhu, Kai-Xian,Jensen, Paul,Try, Andrew C.. "Synthesis of symmetric diester-functionalised Troeger's base analogues". supporting information; experimental part. p. 4662 - 4670. Retrieved 2010/10/19.