Chemical Property of 2-amino-3-hydroxy-N'-[(2,3,4-trihydroxyphenyl)methyl]propanehydrazide;hydron;chloride
Chemical Property:
- Appearance/Colour:white crystalline solid
- Melting Point:146 °C
- Boiling Point:574.2 °C at 760 mmHg
- Flash Point:301 °C
- PSA：148.07000
- LogP:0.52790
- Storage Temp.:-20°C Freezer
- Sensitive.:Light Sensitive
- Solubility.:H2O: 10 mg/mL
- Water Solubility.:Soluble in water, dimethyl sulfoxide and methanol. Insoluble in ethanol and acetone.
- Hydrogen Bond Donor Count:8
- Hydrogen Bond Acceptor Count:8
- Rotatable Bond Count:5
- Exact Mass:293.0778483
- Heavy Atom Count:19
- Complexity:278
- Purity/Quality:
-
98% *data from raw suppliers
Benserazide, Hydrochloride *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xi
- Hazard Codes:Xi
- Statements:
36/37/38
- Safety Statements:
26-36
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:[H+].C1=CC(=C(C(=C1CNNC(=O)C(CO)N)O)O)O.[Cl-]
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Description
Benserazide is an inhibitor of aromatic L-amino acid decarboxylase (AADC), an enzyme that has dopamine decarboxylase activity. It is also unable to cross the blood-brain barrier. As a result, benserazide blocks the conversion of L-DOPA to dopamine by AADC in the peripheral circulatory system. Benserazide is often combined with L-DOPA in patients with Parkinson’s disease.
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Uses
Used as antiparkinsonian. A peripheral decarboxylase inhibitor Antiparkinsonian;DOPA decarboxylase inhibitor Inhibitor of L-aromatic amino acid decarboxylaseBenserazide hydrochloride is used as an antiparkinsonian. It is a peripheral decarboxylase inhibitor. It is used as an inhibitor for aromatic L-aminoacid decarboxylase. Further, it serves as an inhibitor of tyrosine hydroxylase (TH) and Tryptophan hydroxylase (TPH) inhibitor.
![2-amino-3-hydroxy-N'-[(2,3,4-trihydroxyphenyl)methyl]propanehydrazide;hydron;chloride](http://www.lookchem.com/300w/201001/img/14919-77-8.jpg_ms)
