(2S,4R)-4-[2-chloro-4-((S)-2,2,2-trifluoro-1-methylethoxy)benzenesulfonyl]-1-(1-trifluoromethylcyclopropanecarbonyl)pyrrolidine-2-carboxylic acid (1-cyano-cyclopropyl)amide

Base Information

Chemical Name:(2S,4R)-4-[2-chloro-4-((S)-2,2,2-trifluoro-1-methylethoxy)benzenesulfonyl]-1-(1-trifluoromethylcyclopropanecarbonyl)pyrrolidine-2-carboxylic acid (1-cyano-cyclopropyl)amide
CAS No.:1252634-14-2
Molecular Formula:C₂₃H₂₂ClF₆N₃O₅S
Molecular Weight:601.954
Hs Code.:

(2S,4R)-4-[2-chloro-4-((S)-2,2,2-trifluoro-1-methylethoxy)benzenesulfonyl]-1-(1-trifluoromethylcyclopropanecarbonyl)pyrrolidine-2-carboxylic acid (1-cyano-cyclopropyl)amide

Synonyms:(2S,4R)-4-[2-chloro-4-((S)-2,2,2-trifluoro-1-methylethoxy)benzenesulfonyl]-1-(1-trifluoromethylcyclopropanecarbonyl)pyrrolidine-2-carboxylic acid (1-cyano-cyclopropyl)amide

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Chemical Property of (2S,4R)-4-[2-chloro-4-((S)-2,2,2-trifluoro-1-methylethoxy)benzenesulfonyl]-1-(1-trifluoromethylcyclopropanecarbonyl)pyrrolidine-2-carboxylic acid (1-cyano-cyclopropyl)amide

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Technology Process of (2S,4R)-4-[2-chloro-4-((S)-2,2,2-trifluoro-1-methylethoxy)benzenesulfonyl]-1-(1-trifluoromethylcyclopropanecarbonyl)pyrrolidine-2-carboxylic acid (1-cyano-cyclopropyl)amide

There total 16 articles about (2S,4R)-4-[2-chloro-4-((S)-2,2,2-trifluoro-1-methylethoxy)benzenesulfonyl]-1-(1-trifluoromethylcyclopropanecarbonyl)pyrrolidine-2-carboxylic acid (1-cyano-cyclopropyl)amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1252634-18-6
lithium (2S,4R)-4-[2-chloro-4-((S)-2,2,2-trifluoro-1-methylethoxy)benzenesulfonyl]-1-(1-trifluoromethylcyclopropanecarbonyl)pyrrolidine-2-carboxylate

: 127946-77-4
1-amino-1-cyclopropanecarbonitrile hydrochloride

: (2R,4R)-4-[2-chloro-4-(2,2,2-trifluoro-1-methylethoxy)benzenesulfonyl]-1-(1-trifluoromethylcyclopropanecarbonyl)pyrrolidine-2-carboxylic acid (1-cyanocyclopropyl)amide

: 1252634-14-2
(2S,4R)-4-[2-chloro-4-((S)-2,2,2-trifluoro-1-methylethoxy)benzenesulfonyl]-1-(1-trifluoromethylcyclopropanecarbonyl)pyrrolidine-2-carboxylic acid (1-cyano-cyclopropyl)amide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield:

: (2S,4R)-4-[2-chloro-4-((S)-2,2,2-trifluoro-1-methylethoxy)phenylsulfanyl]-1-(1-trifluoromethylcyclopropanecarbonyl)pyrrolidine-2-carboxylic acid (1-cyanocyclopropyl)amide

: 1252634-14-2
(2S,4R)-4-[2-chloro-4-((S)-2,2,2-trifluoro-1-methylethoxy)benzenesulfonyl]-1-(1-trifluoromethylcyclopropanecarbonyl)pyrrolidine-2-carboxylic acid (1-cyano-cyclopropyl)amide

Guidance literature:: With Oxone; In methanol; water; at 10 - 20 ℃; for 20h;

Reference yield:

: 277756-46-4
1-(trifluoromethyl)cyclopropanecarboxylic acid

: 1252634-14-2
(2S,4R)-4-[2-chloro-4-((S)-2,2,2-trifluoro-1-methylethoxy)benzenesulfonyl]-1-(1-trifluoromethylcyclopropanecarbonyl)pyrrolidine-2-carboxylic acid (1-cyano-cyclopropyl)amide

Guidance literature:: Multi-step reaction with 6 steps

1: oxalyl dichloride / toluene; N,N-dimethyl-formamide / 4.92 h / 2 - 20 °C

2: triethylamine / toluene; N,N-dimethyl-formamide; tetrahydrofuran / 20 h / 0 - 20 °C

3: sodium 2-ethylhexanoic acid / water / 20 h / 53 °C

4: triethylamine; dmap / tetrahydrofuran / 20.25 h / 2 - 20 °C

5: potassium carbonate / tetrahydrofuran; N,N-dimethyl acetamide / 5.5 h / 20 - 29 °C

6: Oxone / water; methanol / 20 h / 10 - 20 °C

With dmap; Oxone; oxalyl dichloride; potassium carbonate; triethylamine; sodium 2-ethylhexanoic acid; In tetrahydrofuran; methanol; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide; toluene;