(S)-benzyl 2-((S)-2-(2-amino-3-(3-((S)-2-(benzyloxycarbonylamino)-3-tert-butoxy-3-oxopropyl)-2-(triethylsilyl)-1H-indol-6-yl)-4-methyl-2-((S)-5-oxopyrrolilidine-2-carboxamido)pentanamido)-4-methylpentanamido)-3-methylbutanoate

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Chemical Name:(S)-benzyl 2-((S)-2-(2-amino-3-(3-((S)-2-(benzyloxycarbonylamino)-3-tert-butoxy-3-oxopropyl)-2-(triethylsilyl)-1H-indol-6-yl)-4-methyl-2-((S)-5-oxopyrrolilidine-2-carboxamido)pentanamido)-4-methylpentanamido)-3-methylbutanoate
CAS No.:1189587-54-9
Molecular Formula:C₅₈H₈₂N₆O₁₀Si
Molecular Weight:1051.41
Hs Code.:

(S)-benzyl 2-((S)-2-(2-amino-3-(3-((S)-2-(benzyloxycarbonylamino)-3-tert-butoxy-3-oxopropyl)-2-(triethylsilyl)-1H-indol-6-yl)-4-methyl-2-((S)-5-oxopyrrolilidine-2-carboxamido)pentanamido)-4-methylpentanamido)-3-methylbutanoate

Synonyms:(S)-benzyl 2-((S)-2-(2-amino-3-(3-((S)-2-(benzyloxycarbonylamino)-3-tert-butoxy-3-oxopropyl)-2-(triethylsilyl)-1H-indol-6-yl)-4-methyl-2-((S)-5-oxopyrrolilidine-2-carboxamido)pentanamido)-4-methylpentanamido)-3-methylbutanoate

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Chemical Property of (S)-benzyl 2-((S)-2-(2-amino-3-(3-((S)-2-(benzyloxycarbonylamino)-3-tert-butoxy-3-oxopropyl)-2-(triethylsilyl)-1H-indol-6-yl)-4-methyl-2-((S)-5-oxopyrrolilidine-2-carboxamido)pentanamido)-4-methylpentanamido)-3-methylbutanoate

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Technology Process of (S)-benzyl 2-((S)-2-(2-amino-3-(3-((S)-2-(benzyloxycarbonylamino)-3-tert-butoxy-3-oxopropyl)-2-(triethylsilyl)-1H-indol-6-yl)-4-methyl-2-((S)-5-oxopyrrolilidine-2-carboxamido)pentanamido)-4-methylpentanamido)-3-methylbutanoate

There total 2 articles about (S)-benzyl 2-((S)-2-(2-amino-3-(3-((S)-2-(benzyloxycarbonylamino)-3-tert-butoxy-3-oxopropyl)-2-(triethylsilyl)-1H-indol-6-yl)-4-methyl-2-((S)-5-oxopyrrolilidine-2-carboxamido)pentanamido)-4-methylpentanamido)-3-methylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1189587-53-8
(S)-benzyl 2-((S)-2-(2-amino-3-(3-((S)-2-(benzyloxycarbonylamino)-3-tert-butoxy-3-oxopropyl)-2-(triethylsilyl)-1H-indol-6-yl)-4-methylpentanamido)-4-methylpentanamido)-3-methylbutanoate

: 98-79-3
L-Pyroglutamic acid

: 1189587-54-9
(S)-benzyl 2-((S)-2-(2-amino-3-(3-((S)-2-(benzyloxycarbonylamino)-3-tert-butoxy-3-oxopropyl)-2-(triethylsilyl)-1H-indol-6-yl)-4-methyl-2-((S)-5-oxopyrrolilidine-2-carboxamido)pentanamido)-4-methylpentanamido)-3-methylbutanoate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; at 0 ℃; for 8h;
DOI:10.1021/ja909870g

Reference yield: 59.0%

: 1189587-53-8
(S)-benzyl 2-((S)-2-(2-amino-3-(3-((S)-2-(benzyloxycarbonylamino)-3-tert-butoxy-3-oxopropyl)-2-(triethylsilyl)-1H-indol-6-yl)-4-methylpentanamido)-4-methylpentanamido)-3-methylbutanoate

: 98-79-3
L-Pyroglutamic acid

: 1189587-54-9
(S)-benzyl 2-((S)-2-(2-amino-3-(3-((S)-2-(benzyloxycarbonylamino)-3-tert-butoxy-3-oxopropyl)-2-(triethylsilyl)-1H-indol-6-yl)-4-methyl-2-((S)-5-oxopyrrolilidine-2-carboxamido)pentanamido)-4-methylpentanamido)-3-methylbutanoate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; at 0 ℃; for 8h;
DOI:10.1021/ja909870g