(R)-4-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-3-(4-methoxy-benzyloxy)-butan-1-ol

Base Information

Chemical Name:(R)-4-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-3-(4-methoxy-benzyloxy)-butan-1-ol
CAS No.:119649-97-7
Molecular Formula:C₁₇H₂₆O₅
Molecular Weight:310.39
Hs Code.:

Synonyms:(R)-4-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-3-(4-methoxy-benzyloxy)-butan-1-ol

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Chemical Property of (R)-4-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-3-(4-methoxy-benzyloxy)-butan-1-ol

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Technology Process of (R)-4-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-3-(4-methoxy-benzyloxy)-butan-1-ol

There total 7 articles about (R)-4-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-3-(4-methoxy-benzyloxy)-butan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 77-76-9
2,2-dimethoxy-propane

: 163452-37-7
(2S,4R)-1,2,6-trihydroxy-4-<(p-methoxybenzyl)oxy>hexane

: 119649-97-7
(R)-4-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-3-(4-methoxy-benzyloxy)-butan-1-ol

Guidance literature:: With camphor-10-sulfonic acid; In dichloromethane; for 1.5h; Ambient temperature;
DOI:10.1021/ja00112a006

Reference yield:

: 824-94-2
p-methoxybenzyl chloride

: 119649-97-7
(R)-4-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-3-(4-methoxy-benzyloxy)-butan-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) LiBHEt₃, 2.) 30percent aq. H₂O₂, 3.0 M aq. NaOH, 3.) KH

2: 78 percent / aq. p-TsOH / tetrahydrofuran / 5 h / Heating

3: 94 percent / LiAlH₄ / tetrahydrofuran / 5 h / Ambient temperature

4: 60 percent / camphorsulfonic acid / CH₂Cl₂ / 1.5 h / Ambient temperature

With sodium hydroxide; lithium aluminium tetrahydride; camphor-10-sulfonic acid; dihydrogen peroxide; potassium hydride; lithium triethylborohydride; toluene-4-sulfonic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja00112a006

Reference yield:

: (1S,3R,5R)-4-<(p-methoxybenzyl)oxy>-6,8-dioxobicyclo<3.2.1>octane

: 119649-97-7
(R)-4-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-3-(4-methoxy-benzyloxy)-butan-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 78 percent / aq. p-TsOH / tetrahydrofuran / 5 h / Heating

2: 94 percent / LiAlH₄ / tetrahydrofuran / 5 h / Ambient temperature

3: 60 percent / camphorsulfonic acid / CH₂Cl₂ / 1.5 h / Ambient temperature

With lithium aluminium tetrahydride; camphor-10-sulfonic acid; toluene-4-sulfonic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja00112a006