L-aspartyl-D-phenylglycine (-)-endo-1,3,3-trimethyl-7-oxabicyclo<2.2.1>heptan-2-yl ester

Base Information

Chemical Name:L-aspartyl-D-phenylglycine (-)-endo-1,3,3-trimethyl-7-oxabicyclo<2.2.1>heptan-2-yl ester
CAS No.:103251-85-0
Molecular Formula:C₂₁H₂₈N₂O₆
Molecular Weight:404.463
Hs Code.:

Synonyms:L-aspartyl-D-phenylglycine (-)-endo-1,3,3-trimethyl-7-oxabicyclo<2.2.1>heptan-2-yl ester

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Chemical Property of L-aspartyl-D-phenylglycine (-)-endo-1,3,3-trimethyl-7-oxabicyclo<2.2.1>heptan-2-yl ester

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Technology Process of L-aspartyl-D-phenylglycine (-)-endo-1,3,3-trimethyl-7-oxabicyclo<2.2.1>heptan-2-yl ester

There total 8 articles about L-aspartyl-D-phenylglycine (-)-endo-1,3,3-trimethyl-7-oxabicyclo<2.2.1>heptan-2-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 875-74-1
(R)-phenylglycine

: 103251-85-0
L-aspartyl-D-phenylglycine (-)-endo-1,3,3-trimethyl-7-oxabicyclo<2.2.1>heptan-2-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 62 percent / 2N NaOH / dioxane / 2 h

2: dicyclohexylcarbodiimide, 4-(dimethylamino)pyridine / CH₂Cl₂ / 1.) -78 deg C, 0.5 h, 2.) -23 deg C

3: 5N HCl / acetone

4: 2.) H₂ / 2.) Pd/C / 1.) THF, 24 h, 2.) MeOH, 50 psi

With hydrogenchloride; dmap; sodium hydroxide; hydrogen; dicyclohexyl-carbodiimide; palladium on activated charcoal; In 1,4-dioxane; dichloromethane; acetone;
DOI:10.1021/jm00165a027

Reference yield:

: 103251-83-8
(+/-)-1,3,3-trimethyl-7-oxabicyclo<2.2.1>heptan-2-one

: 103251-85-0
L-aspartyl-D-phenylglycine (-)-endo-1,3,3-trimethyl-7-oxabicyclo<2.2.1>heptan-2-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1 M LiAlH₄ / tetrahydrofuran; diethyl ether / 0.5 h / 0 °C

2: dicyclohexylcarbodiimide, 4-(dimethylamino)pyridine / CH₂Cl₂ / 1.) -78 deg C, 0.5 h, 2.) -23 deg C

3: 5N HCl / acetone

4: 2.) H₂ / 2.) Pd/C / 1.) THF, 24 h, 2.) MeOH, 50 psi

With hydrogenchloride; dmap; lithium aluminium tetrahydride; hydrogen; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; dichloromethane; acetone;
DOI:10.1021/jm00165a027

Reference yield:

: 16679-41-7
N-<(o-nitrophenyl)sulfenyl>-D-phenylglycine

: 103251-85-0
L-aspartyl-D-phenylglycine (-)-endo-1,3,3-trimethyl-7-oxabicyclo<2.2.1>heptan-2-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: dicyclohexylcarbodiimide, 4-(dimethylamino)pyridine / CH₂Cl₂ / 1.) -78 deg C, 0.5 h, 2.) -23 deg C

2: 5N HCl / acetone

3: 2.) H₂ / 2.) Pd/C / 1.) THF, 24 h, 2.) MeOH, 50 psi

With hydrogenchloride; dmap; hydrogen; dicyclohexyl-carbodiimide; palladium on activated charcoal; In dichloromethane; acetone;
DOI:10.1021/jm00165a027