(R)-3-(2-aminopropyl)-7-benzyloxyindole oxalate

Base Information

• Chemical Name: (R)-3-(2-aminopropyl)-7-benzyloxyindole oxalate
• CAS No.: 244081-36-5
• Molecular Formula: C₂H₂O₄*C₁₈H₂₀N₂O
• Molecular Weight: 370.405
• Mol file: 244081-36-5.mol

Synonyms:(R)-3-(2-aminopropyl)-7-benzyloxyindole oxalate

Chemical Property of (R)-3-(2-aminopropyl)-7-benzyloxyindole oxalate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-3-(2-aminopropyl)-7-benzyloxyindole oxalate

There total 7 articles about (R)-3-(2-aminopropyl)-7-benzyloxyindole oxalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

7-benzyloxy-3-[2(R)-(9-fluorenylmethoxycarbonylamino)propionyl]-1H-indole + oxalic acid (144-62-7,97993-78-7) → (R)-3-(2-aminopropyl)-7-benzyloxyindole oxalate (244081-36-5) + (R)-3-(2-aminopropyl)-7-benzyloxyindole (244081-35-4)

Guidance literature:

7-benzyloxy-3-[2(R)-(9-fluorenylmethoxycarbonylamino)propionyl]-1H-indole; With sodium tetrahydroborate; In isopropyl alcohol; for 4h;

oxalic acid;

DOI:10.1021/op0341869

Reference yield:

7-benzyloxyindole (20289-27-4) → (R)-3-(2-aminopropyl)-7-benzyloxyindole oxalate (244081-36-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: methylmagnesium bromide / dichloromethane; diethyl ether / 1 h / 20 °C / Inert atmosphere

1.2: 1 h / 20 °C / Inert atmosphere

1.3: 0.25 h / Inert atmosphere; Cooling with ice

2.1: sodium tetrahydroborate / isopropyl alcohol / 4 h

With sodium tetrahydroborate; methylmagnesium bromide; In diethyl ether; dichloromethane; isopropyl alcohol;

DOI:10.1021/op0341869

Reference yield:

7-benzyloxy-3-[2(R)-(9-fluorenylmethoxycarbonylamino)propionyl]-1H-indole → (R)-3-(2-aminopropyl)-7-benzyloxyindole oxalate (244081-36-5)

Guidance literature:

Multi-step reaction with 2 steps

1: borane-THF / tetrahydrofuran / 24 h

2: ethyl acetate / 2 h / 20 °C

With borane-THF; In tetrahydrofuran; ethyl acetate;

DOI:10.1021/op0341869

upstream raw materials:

oxalic acid

(R)-3-(2-aminopropyl)-7-benzyloxyindole

7-benzyloxyindole

Downstream raw materials:

(2R)-7-benzyloxy-3-[2-(tert-butoxycarbonylamino)propyl]-1H-indole