(2R,6R)-2-[2-(1,3-dioxan-2-yl)ethyl]-1-[(1R)-2-hydroxy-1-phenylethyl]-6-propylpiperidine

Base Information

Chemical Name:(2R,6R)-2-[2-(1,3-dioxan-2-yl)ethyl]-1-[(1R)-2-hydroxy-1-phenylethyl]-6-propylpiperidine
CAS No.:503843-21-8
Molecular Formula:C₂₂H₃₅NO₃
Molecular Weight:361.525
Hs Code.:

Synonyms:(2R,6R)-2-[2-(1,3-dioxan-2-yl)ethyl]-1-[(1R)-2-hydroxy-1-phenylethyl]-6-propylpiperidine

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Chemical Property of (2R,6R)-2-[2-(1,3-dioxan-2-yl)ethyl]-1-[(1R)-2-hydroxy-1-phenylethyl]-6-propylpiperidine

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Technology Process of (2R,6R)-2-[2-(1,3-dioxan-2-yl)ethyl]-1-[(1R)-2-hydroxy-1-phenylethyl]-6-propylpiperidine

There total 3 articles about (2R,6R)-2-[2-(1,3-dioxan-2-yl)ethyl]-1-[(1R)-2-hydroxy-1-phenylethyl]-6-propylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: (1,3-dioxan-2-yl)ethylmagnesium bromide

: 503843-19-4
(3R,5R)-3-phenyl-5-propyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine

: 503843-21-8
(2R,6R)-2-[2-(1,3-dioxan-2-yl)ethyl]-1-[(1R)-2-hydroxy-1-phenylethyl]-6-propylpiperidine

Guidance literature:: In tetrahydrofuran; at 0 ℃; for 20h;
DOI:10.1021/jo0266083

Reference yield:

: 152615-80-0
(3R,8aS)-5-oxo-3-phenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo<3,2-a>pyridine

: 503843-21-8
(2R,6R)-2-[2-(1,3-dioxan-2-yl)ethyl]-1-[(1R)-2-hydroxy-1-phenylethyl]-6-propylpiperidine

Guidance literature:: Multi-step reaction with 3 steps

1: CuCN; BF₃*Et₂O / diethyl ether / 2 h / -78 °C

2: 68 percent / Red-Al / tetrahydrofuran; toluene / 24 h / -78 °C

3: 77 percent / tetrahydrofuran / 20 h / 0 °C

With boron trifluoride diethyl etherate; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; diethyl ether; toluene;
DOI:10.1021/jo0266083

Reference yield:

: 177981-22-5
(6R)-1-[(1R)-2-hydroxy-1-phenylethyl]-6-propyl-2-piperidone

: 503843-21-8
(2R,6R)-2-[2-(1,3-dioxan-2-yl)ethyl]-1-[(1R)-2-hydroxy-1-phenylethyl]-6-propylpiperidine

Guidance literature:: Multi-step reaction with 2 steps

1: 68 percent / Red-Al / tetrahydrofuran; toluene / 24 h / -78 °C

2: 77 percent / tetrahydrofuran / 20 h / 0 °C

With sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; toluene;
DOI:10.1021/jo0266083