(3R,5R)-3-phenyl-5-propyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine

Base Information

Chemical Name:(3R,5R)-3-phenyl-5-propyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine
CAS No.:503843-19-4
Molecular Formula:C₁₆H₂₃NO
Molecular Weight:245.365
Hs Code.:

Synonyms:(3R,5R)-3-phenyl-5-propyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3R,5R)-3-phenyl-5-propyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine

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Technology Process of (3R,5R)-3-phenyl-5-propyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine

There total 2 articles about (3R,5R)-3-phenyl-5-propyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 177981-22-5
(6R)-1-[(1R)-2-hydroxy-1-phenylethyl]-6-propyl-2-piperidone

: (2R)-1-[(1R)-2-hydroxy-1-phenylethyl]-2-propylpiperidine

: 503843-19-4
(3R,5R)-3-phenyl-5-propyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine

Guidance literature:: With sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; toluene; at -78 ℃; for 24h;
DOI:10.1021/jo0266083

Reference yield:

: 152615-80-0
(3R,8aS)-5-oxo-3-phenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo<3,2-a>pyridine

: 503843-19-4
(3R,5R)-3-phenyl-5-propyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine

Guidance literature:: Multi-step reaction with 2 steps

1: CuCN; BF₃*Et₂O / diethyl ether / 2 h / -78 °C

2: 68 percent / Red-Al / tetrahydrofuran; toluene / 24 h / -78 °C

With boron trifluoride diethyl etherate; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; diethyl ether; toluene;
DOI:10.1021/jo0266083