(3S)-ethyl 3-(3-bromo-5-(2-cyanopropan-2-yl)phenyl)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)propanoate

Base Information

Chemical Name:(3S)-ethyl 3-(3-bromo-5-(2-cyanopropan-2-yl)phenyl)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)propanoate
CAS No.:1541199-04-5
Molecular Formula:C₂₈H₃₃BrN₆O₆
Molecular Weight:629.511
Hs Code.:

(3S)-ethyl 3-(3-bromo-5-(2-cyanopropan-2-yl)phenyl)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)propanoate

Synonyms:(3S)-ethyl 3-(3-bromo-5-(2-cyanopropan-2-yl)phenyl)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)propanoate

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Chemical Property of (3S)-ethyl 3-(3-bromo-5-(2-cyanopropan-2-yl)phenyl)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)propanoate

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Technology Process of (3S)-ethyl 3-(3-bromo-5-(2-cyanopropan-2-yl)phenyl)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)propanoate

There total 9 articles about (3S)-ethyl 3-(3-bromo-5-(2-cyanopropan-2-yl)phenyl)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 290826-72-1
2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetic acid

: 1541198-95-1
(S)-ethyl 3-amino-3-(3-bromo-5-(2-cyanopropan-2-yl)phenyl)propanoate hydrochloride

: 1541199-04-5
(3S)-ethyl 3-(3-bromo-5-(2-cyanopropan-2-yl)phenyl)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)propanoate

Guidance literature:: 2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetic acid; (S)-ethyl 3-amino-3-(3-bromo-5-(2-cyanopropan-2-yl)phenyl)propanoate hydrochloride; With benzotriazol-1-ol; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 0.166667h; Inert atmosphere;

With diisopropyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

Reference yield:

: ethyl 3-amino-3-(3-bromo-5-(2-cyanopropan-2-yl)phenyl)propanoate hydrochloride

: 1541199-04-5
(3S)-ethyl 3-(3-bromo-5-(2-cyanopropan-2-yl)phenyl)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)propanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium dihydrogenphosphate; Amano Lipase PS; sodium hydroxide / water / 20 °C / pH 8.2 / Enzymatic reaction

2.1: acetonitrile; water

3.1: hydrogenchloride / 2 h / Reflux

4.1: benzotriazol-1-ol / N,N-dimethyl-formamide; dichloromethane / 0.17 h / 20 °C / Inert atmosphere

4.2: 20 °C / Inert atmosphere

With hydrogenchloride; potassium dihydrogenphosphate; Amano Lipase PS; benzotriazol-1-ol; sodium hydroxide; In dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1541198-99-5
2-(3-bromo-5-formylphenyl)-2-methylpropanenitrile

: 1541199-04-5
(3S)-ethyl 3-(3-bromo-5-(2-cyanopropan-2-yl)phenyl)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)propanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: ammonium acetate / ethanol / 8 h / Reflux

2.1: hydrogenchloride / ethanol / 2 h / Reflux

3.1: potassium dihydrogenphosphate; Amano Lipase PS; sodium hydroxide / water / 20 °C / pH 8.2 / Enzymatic reaction

4.1: acetonitrile; water

5.1: hydrogenchloride / 2 h / Reflux

6.1: benzotriazol-1-ol / N,N-dimethyl-formamide; dichloromethane / 0.17 h / 20 °C / Inert atmosphere

6.2: 20 °C / Inert atmosphere

With hydrogenchloride; potassium dihydrogenphosphate; Amano Lipase PS; ammonium acetate; benzotriazol-1-ol; sodium hydroxide; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;