2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetic acid

Base Information

Chemical Name:2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetic acid
CAS No.:290826-72-1
Molecular Formula:C₁₃H₁₆N₄O₅
Molecular Weight:308.294
Hs Code.:

Synonyms:2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetic acid

Suppliers and Price of 2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetic acid

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetic acid

There total 2 articles about 2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1541197-48-1
C₁₅H₂₀N₄O₅

: 290826-72-1
2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetic acid

Guidance literature:: With sodium hydroxide; at 10 - 20 ℃; for 1.5h;

Reference yield:

: 240431-49-6
3-hydroxy-5-[(5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino]benzoic acid

: 290826-72-1
2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: diisopropyl-carbodiimide / N,N-dimethyl-formamide; dichloromethane / 20 °C / Inert atmosphere

2: sodium hydroxide / 1.5 h / 10 - 20 °C

With sodium hydroxide; diisopropyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: ethyl (3R)-3-amino-3-(2-hydroxy-3,5-dimethylphenyl)propanoate hydrochloride

: 290826-72-1
2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetic acid

: C₂₄H₂₉N₅O₇C₂H₄

Guidance literature:: 2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetic acid; With trifluoroacetic acid; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 0.25h;

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 0.5h;

ethyl (3R)-3-amino-3-(2-hydroxy-3,5-dimethylphenyl)propanoate hydrochloride; With triethylamine; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 18h;