N-tert-butoxycarbonyl-D-phenylalanyl-L-cysteinyl(Acm)-D-tryptophyl-L-leucyl-α-methylalanine methyl ester

Base Information

Chemical Name:N-tert-butoxycarbonyl-D-phenylalanyl-L-cysteinyl(Acm)-D-tryptophyl-L-leucyl-α-methylalanine methyl ester
CAS No.:128718-61-6
Molecular Formula:C₄₂H₅₉N₇O₉S
Molecular Weight:838.038
Hs Code.:

Synonyms:N-tert-butoxycarbonyl-D-phenylalanyl-L-cysteinyl(Acm)-D-tryptophyl-L-leucyl-α-methylalanine methyl ester

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Chemical Property of N-tert-butoxycarbonyl-D-phenylalanyl-L-cysteinyl(Acm)-D-tryptophyl-L-leucyl-α-methylalanine methyl ester

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Technology Process of N-tert-butoxycarbonyl-D-phenylalanyl-L-cysteinyl(Acm)-D-tryptophyl-L-leucyl-α-methylalanine methyl ester

There total 9 articles about N-tert-butoxycarbonyl-D-phenylalanyl-L-cysteinyl(Acm)-D-tryptophyl-L-leucyl-α-methylalanine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.8%

: 100578-67-4
HCl*H-Leu-Aib-OMe

: 128719-33-5
Boc-D-Phe-Cys(Acm)-D-Trp-OH

: 128718-61-6
N-tert-butoxycarbonyl-D-phenylalanyl-L-cysteinyl(Acm)-D-tryptophyl-L-leucyl-α-methylalanine methyl ester

Guidance literature:: With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 4 ℃;

Reference yield:

: 19746-37-3
N-t-butoxycarbonyl-S-acetamidomethyl-L-cysteine

: 128718-61-6
N-tert-butoxycarbonyl-D-phenylalanyl-L-cysteinyl(Acm)-D-tryptophyl-L-leucyl-α-methylalanine methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: N-methylmorpholine / dimethylformamide / 0.03 h

2: Et₃N / dimethylformamide / 1.) -10 deg C, 30 min, 2.) 4 deg C, 2 h

3: 88 percent / 2N HCl / ethyl acetate / 1 h / Ambient temperature

4: Et₃N / dimethylformamide / 1.) -10 deg C, 30 min, 2.) 4 deg C, 2 h

5: 93.2 percent / 2N NaOH / methanol / 1 h / Ambient temperature

6: 47.8 percent / dicyclohexylcarbodiimide (DCCI), 1-hydroxybenzotriazole (HOBt), Et₃N / dimethylformamide / 4 °C

With 4-methyl-morpholine; hydrogenchloride; sodium hydroxide; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In methanol; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 18942-49-9
Boc-D-Phe-OH

: 128718-61-6
N-tert-butoxycarbonyl-D-phenylalanyl-L-cysteinyl(Acm)-D-tryptophyl-L-leucyl-α-methylalanine methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: N-methylmorpholine / dimethylformamide / 0.03 h

2: Et₃N / dimethylformamide / 1.) -10 deg C, 30 min, 2.) 4 deg C, 2 h

3: 93.2 percent / 2N NaOH / methanol / 1 h / Ambient temperature

4: 47.8 percent / dicyclohexylcarbodiimide (DCCI), 1-hydroxybenzotriazole (HOBt), Et₃N / dimethylformamide / 4 °C

With 4-methyl-morpholine; sodium hydroxide; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In methanol; N,N-dimethyl-formamide;