5-isopropyl-2,3,4-trimethoxybenzoic acid 2,5-dioxo-pyrrolidin-1-yl ester

Base Information

Chemical Name:5-isopropyl-2,3,4-trimethoxybenzoic acid 2,5-dioxo-pyrrolidin-1-yl ester
CAS No.:936847-40-4
Molecular Formula:C₁₇H₂₁NO₇
Molecular Weight:351.356
Hs Code.:

Synonyms:5-isopropyl-2,3,4-trimethoxybenzoic acid 2,5-dioxo-pyrrolidin-1-yl ester

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Chemical Property of 5-isopropyl-2,3,4-trimethoxybenzoic acid 2,5-dioxo-pyrrolidin-1-yl ester

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Technology Process of 5-isopropyl-2,3,4-trimethoxybenzoic acid 2,5-dioxo-pyrrolidin-1-yl ester

There total 3 articles about 5-isopropyl-2,3,4-trimethoxybenzoic acid 2,5-dioxo-pyrrolidin-1-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 936847-39-1
1-isopropenyl-2,3,4-trimethoxybenzene

: 936847-40-4
5-isopropyl-2,3,4-trimethoxybenzoic acid 2,5-dioxo-pyrrolidin-1-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 98 percent / hydrogen / Pd/C / ethanol / 1551.44 Torr

2.1: t-BuLi; HMPA / pentane; tetrahydrofuran / 0.67 h / -78 - -40 °C

2.2: 86 percent / pentane; tetrahydrofuran / 4 h / -78 - 0 °C

3.1: 93 percent / EDAC*HCl; triethylamine / CH₂Cl₂ / 3 h / 20 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; hydrogen; tert.-butyl lithium; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; pentane;
DOI:10.1021/jm061400l

Reference yield:

: 13909-73-4
2',3',4'-trimethoxyacetophenone

: 936847-40-4
5-isopropyl-2,3,4-trimethoxybenzoic acid 2,5-dioxo-pyrrolidin-1-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 92 percent / tetrahydrofuran; diethyl ether / 2 h / 0 - 20 °C

2.1: 98 percent / hydrogen / Pd/C / ethanol / 1551.44 Torr

3.1: t-BuLi; HMPA / pentane; tetrahydrofuran / 0.67 h / -78 - -40 °C

3.2: 86 percent / pentane; tetrahydrofuran / 4 h / -78 - 0 °C

4.1: 93 percent / EDAC*HCl; triethylamine / CH₂Cl₂ / 3 h / 20 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; hydrogen; tert.-butyl lithium; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; pentane;
DOI:10.1021/jm061400l

Reference yield:

: 91765-04-7
1-isopropyl-2,3,4-trimethoxybenzene

: 936847-40-4
5-isopropyl-2,3,4-trimethoxybenzoic acid 2,5-dioxo-pyrrolidin-1-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: t-BuLi; HMPA / pentane; tetrahydrofuran / 0.67 h / -78 - -40 °C

1.2: 86 percent / pentane; tetrahydrofuran / 4 h / -78 - 0 °C

2.1: 93 percent / EDAC*HCl; triethylamine / CH₂Cl₂ / 3 h / 20 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; tert.-butyl lithium; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; dichloromethane; pentane;
DOI:10.1021/jm061400l