1-isopropenyl-2,3,4-trimethoxybenzene

Base Information

• Chemical Name: 1-isopropenyl-2,3,4-trimethoxybenzene
• CAS No.: 936847-39-1
• Molecular Formula: C₁₂H₁₆O₃
• Molecular Weight: 208.257
• Mol file: 936847-39-1.mol

Synonyms:1-isopropenyl-2,3,4-trimethoxybenzene

Chemical Property of 1-isopropenyl-2,3,4-trimethoxybenzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-isopropenyl-2,3,4-trimethoxybenzene

There total 2 articles about 1-isopropenyl-2,3,4-trimethoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2',3',4'-trimethoxyacetophenone (13909-73-4) + methylmagnesium bromide (75-16-1) → 1-isopropenyl-2,3,4-trimethoxybenzene (936847-39-1)

Guidance literature:

In tetrahydrofuran; diethyl ether; at 0 - 20 ℃; for 2h;

DOI:10.1021/jm061400l

Reference yield: 79.0%

2-(2-bromo-3,4,5-trimethoxyphenyl)-2-methylpropanal (1206451-04-8) → 1-isopropenyl-2,3,4-trimethoxybenzene (936847-39-1)

Guidance literature:

With 2BF₄⁽¹⁺⁾*C₂₇H₅₀P₂*2H⁽¹⁺⁾; palladium diacetate; caesium carbonate; In toluene; at 110 ℃; for 14h; Inert atmosphere;

DOI:10.1002/adsc.201100140

Reference yield: 98.0%

1-isopropenyl-2,3,4-trimethoxybenzene (936847-39-1) → 1-isopropyl-2,3,4-trimethoxybenzene (91765-04-7)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; under 1551.44 Torr;

DOI:10.1021/jm061400l

upstream raw materials:

2',3',4'-trimethoxyacetophenone

methylmagnesium bromide

2-(2-bromo-3,4,5-trimethoxyphenyl)-2-methylpropanal

Downstream raw materials:

1-isopropyl-2,3,4-trimethoxybenzene

5-isopropyl-2,3,4-trimethoxybenzoic acid

5-isopropyl-2,3,4-trimethoxybenzoic acid 2,5-dioxo-pyrrolidin-1-yl ester

(3,4-dihydroisoquinolin-2(1H)-yl)(5-isopropyl-2,3,4-trimethoxyphenyl)methanone

Refernces

• 1、 Tang, Guozhi,Yang, Chao-Yie,Nikolovska-Coleska, Zaneta,Guo, Jie,Qiu, Su,Wang, Renxiao,Gao, Wei,Wang, Guoping,Stuckey, Jeanne,Krajewski, Krzysztof,Jiang, Sheng,Roller, Peter P.,Wang, Shaomeng. "Pyrogallol-based molecules as potent inhibitors of the antiapoptotic Bcl-2 proteins". . p. 1723 - 1726. Retrieved 2007/10/03.