2,4,6-trimethylbenzenesulfonic acid 2-amino-9-[2-(tert-butyldimethylsilyloxy)ethoxymethyl]-9H-purin-6-yl ester

Base Information

Chemical Name:2,4,6-trimethylbenzenesulfonic acid 2-amino-9-[2-(tert-butyldimethylsilyloxy)ethoxymethyl]-9H-purin-6-yl ester
CAS No.:888498-37-1
Molecular Formula:C₂₃H₃₅N₅O₅SSi
Molecular Weight:521.713
Hs Code.:

Synonyms:2,4,6-trimethylbenzenesulfonic acid 2-amino-9-[2-(tert-butyldimethylsilyloxy)ethoxymethyl]-9H-purin-6-yl ester

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Chemical Property of 2,4,6-trimethylbenzenesulfonic acid 2-amino-9-[2-(tert-butyldimethylsilyloxy)ethoxymethyl]-9H-purin-6-yl ester

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Technology Process of 2,4,6-trimethylbenzenesulfonic acid 2-amino-9-[2-(tert-butyldimethylsilyloxy)ethoxymethyl]-9H-purin-6-yl ester

There total 3 articles about 2,4,6-trimethylbenzenesulfonic acid 2-amino-9-[2-(tert-butyldimethylsilyloxy)ethoxymethyl]-9H-purin-6-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 773-64-8
2-mesitylenesulphonyl chloride

: 139767-68-3
2-amino-9-[2-(tert-butyldimethylsilyloxy)ethoxymethyl]-1,9-dihydropurin-6-one

: 888498-37-1
2,4,6-trimethylbenzenesulfonic acid 2-amino-9-[2-(tert-butyldimethylsilyloxy)ethoxymethyl]-9H-purin-6-yl ester

Guidance literature:: With dmap; triethylamine; In acetonitrile; at 20 ℃; for 2h;
DOI:10.1016/j.ejmech.2005.11.007

Reference yield:

: 59277-89-3
acycloguanosine

: 888498-37-1
2,4,6-trimethylbenzenesulfonic acid 2-amino-9-[2-(tert-butyldimethylsilyloxy)ethoxymethyl]-9H-purin-6-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / imidazole / dimethylformamide / 48 h / 20 °C

2: 80 percent / 4-(dimethylamino)pyridine; triethylamine / acetonitrile / 2 h / 20 °C

With 1H-imidazole; dmap; triethylamine; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.ejmech.2005.11.007

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 888498-37-1
2,4,6-trimethylbenzenesulfonic acid 2-amino-9-[2-(tert-butyldimethylsilyloxy)ethoxymethyl]-9H-purin-6-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / imidazole / dimethylformamide / 48 h / 20 °C

2: 80 percent / 4-(dimethylamino)pyridine; triethylamine / acetonitrile / 2 h / 20 °C

With 1H-imidazole; dmap; triethylamine; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.ejmech.2005.11.007