4-amino-5-(5-methyl-1-phenyl-1H-4-pyrazolyl)-4H-1,2,4-triazol-3-yl hydrosulfide

Base Information

• Chemical Name: 4-amino-5-(5-methyl-1-phenyl-1H-4-pyrazolyl)-4H-1,2,4-triazol-3-yl hydrosulfide
• CAS No.: 1266331-58-1
• Molecular Formula: C₁₂H₁₂N₆S
• Molecular Weight: 272.333
• Mol file: 1266331-58-1.mol

Synonyms:4-amino-5-(5-methyl-1-phenyl-1H-4-pyrazolyl)-4H-1,2,4-triazol-3-yl hydrosulfide

Chemical Property of 4-amino-5-(5-methyl-1-phenyl-1H-4-pyrazolyl)-4H-1,2,4-triazol-3-yl hydrosulfide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-amino-5-(5-methyl-1-phenyl-1H-4-pyrazolyl)-4H-1,2,4-triazol-3-yl hydrosulfide

There total 6 articles about 4-amino-5-(5-methyl-1-phenyl-1H-4-pyrazolyl)-4H-1,2,4-triazol-3-yl hydrosulfide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

5-(5-methyl-1-phenyl-1H-4-pyrazolyl)-1,3,4-oxadiazol-2-yl hydrosulfide (816429-52-4) → 4-amino-5-(5-methyl-1-phenyl-1H-4-pyrazolyl)-4H-1,2,4-triazol-3-yl hydrosulfide (1266331-58-1)

Guidance literature:

With hydrazine hydrate; for 24h; Reflux;

DOI:10.1016/j.bioorg.2021.105122

Reference yield:

ethyl 5-methyl-1-phenyl-1H-pyrazole-4-carboxylate (89193-16-8) → 4-amino-5-(5-methyl-1-phenyl-1H-4-pyrazolyl)-4H-1,2,4-triazol-3-yl hydrosulfide (1266331-58-1)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrazine hydrate / ethanol / 4 h / Reflux

2: potassium hydroxide / ethanol / 12 h / Reflux

3: hydrazine hydrate / ethanol / 6 h / Reflux

With hydrazine hydrate; potassium hydroxide; In ethanol;

Reference yield:

5-methyl-1-phenyl-1H-4-pyrazolecarbohydrazide (204260-39-9) → 4-amino-5-(5-methyl-1-phenyl-1H-4-pyrazolyl)-4H-1,2,4-triazol-3-yl hydrosulfide (1266331-58-1)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hydroxide / ethanol / 12 h / Reflux

2: hydrazine hydrate / ethanol / 6 h / Reflux

With hydrazine hydrate; potassium hydroxide; In ethanol;

upstream raw materials:

5-(5-methyl-1-phenyl-1H-4-pyrazolyl)-1,3,4-oxadiazol-2-yl hydrosulfide

ethyl 5-methyl-1-phenyl-1H-pyrazole-4-carboxylate

ethyl 2-[(dimethylamino)methylene]-3-oxobutanoate

5-methyl-1-phenyl-1H-4-pyrazolecarbohydrazide

Downstream raw materials:

3-(5-methyl-1-phenyl-1H-4-pyrazolyl)-6-(3-pyridyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole

3-(5-methyl-1-phenyl-1H-4-pyrazolyl)-6-(4-pyridyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole

4-[3-(5-methyl-1-phenyl-1H-4-pyrazolyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl]aniline

6-(4-methylphenyl)-3-(5-methyl-1-phenyl-1H-4-pyrazolyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole