5-(5-methyl-1-phenyl-1H-4-pyrazolyl)-1,3,4-oxadiazol-2-yl hydrosulfide

Base Information

• Chemical Name: 5-(5-methyl-1-phenyl-1H-4-pyrazolyl)-1,3,4-oxadiazol-2-yl hydrosulfide
• CAS No.: 816429-52-4
• Molecular Formula: C₁₂H₁₀N₄OS
• Molecular Weight: 258.304
• Mol file: 816429-52-4.mol

Synonyms:5-(5-methyl-1-phenyl-1H-4-pyrazolyl)-1,3,4-oxadiazol-2-yl hydrosulfide

Chemical Property of 5-(5-methyl-1-phenyl-1H-4-pyrazolyl)-1,3,4-oxadiazol-2-yl hydrosulfide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(5-methyl-1-phenyl-1H-4-pyrazolyl)-1,3,4-oxadiazol-2-yl hydrosulfide

There total 5 articles about 5-(5-methyl-1-phenyl-1H-4-pyrazolyl)-1,3,4-oxadiazol-2-yl hydrosulfide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

carbon disulfide (75-15-0,12122-00-8) + 5-methyl-1-phenyl-1H-4-pyrazolecarbohydrazide (204260-39-9) → 5-(5-methyl-1-phenyl-1H-4-pyrazolyl)-1,3,4-oxadiazol-2-yl hydrosulfide (816429-52-4)

Guidance literature:

With potassium hydroxide; In ethanol; for 12h; Reflux;

Reference yield: 70.0%

5-methyl-1-phenyl-1H-4-pyrazolecarbohydrazide (204260-39-9) → 5-(5-methyl-1-phenyl-1H-4-pyrazolyl)-1,3,4-oxadiazol-2-yl hydrosulfide (816429-52-4)

Guidance literature:

With carbon disulfide; potassium hydroxide; In ethanol; for 12h; Reflux;

DOI:10.1248/cpb.58.1328

Reference yield:

(E)-ethyl 2-((dimethylamino)methylene)-3-oxobutanoate (203186-58-7) → 5-(5-methyl-1-phenyl-1H-4-pyrazolyl)-1,3,4-oxadiazol-2-yl hydrosulfide (816429-52-4)

Guidance literature:

Multi-step reaction with 3 steps

1: Reflux

2: ethanol / Reflux

3: potassium hydroxide / ethanol / Reflux

With potassium hydroxide; In ethanol;

DOI:10.1002/jhet.913

upstream raw materials:

carbon disulfide

5-methyl-1-phenyl-1H-4-pyrazolecarbohydrazide

(E)-ethyl 2-((dimethylamino)methylene)-3-oxobutanoate

ethyl 2-[(dimethylamino)methylene]-3-oxobutanoate

Downstream raw materials:

4-amino-5-(5-methyl-1-phenyl-1H-4-pyrazolyl)-4H-1,2,4-triazol-3-yl hydrosulfide

3-(Anilinomethyl)-5-(5-methyl-1-phenyl-1H-4-pyrazolyl)-2,3-dihydro-1,3,4-oxadiazole-2-thione

3-[(4-Fluoroanilino)methyl]-5-(5-methyl-1-phenyl-1H-4-pyrazolyl)-2,3-dihydro-1,3,4-oxadiazole-2-thione

3-[(2-Chloroanilino)methyl]-5-(5-methyl-1-phenyl-1H-4-pyrazolyl)-2,3-dihydro-1,3,4-oxadiazole-2-thione