4-[(2S)-2-[(tert-butoxycarbonyl)amino]-3-[(2S)-4-[2-(tert-butoxy)-2-oxoethyl]-2-(2-methoxy-2-oxoethyl)-3-oxopiperazinyl]-3-oxopropyl]benzoic acid

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Chemical Name:4-[(2S)-2-[(tert-butoxycarbonyl)amino]-3-[(2S)-4-[2-(tert-butoxy)-2-oxoethyl]-2-(2-methoxy-2-oxoethyl)-3-oxopiperazinyl]-3-oxopropyl]benzoic acid
CAS No.:340733-32-6
Molecular Formula:C₂₈H₃₉N₃O₁₀
Molecular Weight:577.632
Hs Code.:

Synonyms:4-[(2S)-2-[(tert-butoxycarbonyl)amino]-3-[(2S)-4-[2-(tert-butoxy)-2-oxoethyl]-2-(2-methoxy-2-oxoethyl)-3-oxopiperazinyl]-3-oxopropyl]benzoic acid

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Chemical Property of 4-[(2S)-2-[(tert-butoxycarbonyl)amino]-3-[(2S)-4-[2-(tert-butoxy)-2-oxoethyl]-2-(2-methoxy-2-oxoethyl)-3-oxopiperazinyl]-3-oxopropyl]benzoic acid

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Technology Process of 4-[(2S)-2-[(tert-butoxycarbonyl)amino]-3-[(2S)-4-[2-(tert-butoxy)-2-oxoethyl]-2-(2-methoxy-2-oxoethyl)-3-oxopiperazinyl]-3-oxopropyl]benzoic acid

There total 6 articles about 4-[(2S)-2-[(tert-butoxycarbonyl)amino]-3-[(2S)-4-[2-(tert-butoxy)-2-oxoethyl]-2-(2-methoxy-2-oxoethyl)-3-oxopiperazinyl]-3-oxopropyl]benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 169158-10-5
methyl 2-[(2S)-1-[(2S)-2-[(tert-butoxycarbonyl)amino]-3-(4-formylphenyl)propanoyl]-4-[2-(tert-butoxy)-2-oxoethyl]-3-oxopiperazinyl]acetate

: 340733-32-6
4-[(2S)-2-[(tert-butoxycarbonyl)amino]-3-[(2S)-4-[2-(tert-butoxy)-2-oxoethyl]-2-(2-methoxy-2-oxoethyl)-3-oxopiperazinyl]-3-oxopropyl]benzoic acid

Guidance literature:: With potassium permanganate; acetic acid; In acetone; at 0 - 20 ℃; for 1.66667h;
DOI:10.1248/cpb.49.258

Reference yield:

: 169158-02-5
ethyl (2S)-2-[(tert-butoxycarbonyl)amino]-3-(4-vinylphenyl)propanoate

: 340733-32-6
4-[(2S)-2-[(tert-butoxycarbonyl)amino]-3-[(2S)-4-[2-(tert-butoxy)-2-oxoethyl]-2-(2-methoxy-2-oxoethyl)-3-oxopiperazinyl]-3-oxopropyl]benzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 93 percent / LiOH / methanol; H₂O / 0.33 h / 20 °C

2: 76 percent / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride / CH₂Cl₂ / 2 h / 20 °C

3: 51 percent / NaIO₄; RuCl₃*nH₂O / CCl₄; acetonitrile; H₂O / 1 h / 20 °C

4: 97 percent / KMnO₄; AcOH / acetone / 1.67 h / 0 - 20 °C

With ruthenium trichloride; lithium hydroxide; potassium permanganate; sodium periodate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; tetrachloromethane; dichloromethane; water; acetone; acetonitrile;
DOI:10.1248/cpb.49.258

Reference yield:

: 169158-03-6
(2S)-2-[(tert-butoxycarbonyl)amino]-3-(4-vinylphenyl)propanoic acid

: 340733-32-6
4-[(2S)-2-[(tert-butoxycarbonyl)amino]-3-[(2S)-4-[2-(tert-butoxy)-2-oxoethyl]-2-(2-methoxy-2-oxoethyl)-3-oxopiperazinyl]-3-oxopropyl]benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 76 percent / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride / CH₂Cl₂ / 2 h / 20 °C

2: 51 percent / NaIO₄; RuCl₃*nH₂O / CCl₄; acetonitrile; H₂O / 1 h / 20 °C

3: 97 percent / KMnO₄; AcOH / acetone / 1.67 h / 0 - 20 °C

With ruthenium trichloride; potassium permanganate; sodium periodate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrachloromethane; dichloromethane; water; acetone; acetonitrile;
DOI:10.1248/cpb.49.258