Methyl (S)-dimethyl-3-(2',4',6'-trimethylphenyl)-3-[N-phenyl-((S)-tert-leucyl)]aminopropionate

Base Information

Chemical Name:Methyl (S)-dimethyl-3-(2',4',6'-trimethylphenyl)-3-[N-phenyl-((S)-tert-leucyl)]aminopropionate
CAS No.:313478-63-6
Molecular Formula:C₂₇H₃₈N₂O₃
Molecular Weight:438.61
Hs Code.:

Synonyms:Methyl (S)-dimethyl-3-(2',4',6'-trimethylphenyl)-3-[N-phenyl-((S)-tert-leucyl)]aminopropionate

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Chemical Property of Methyl (S)-dimethyl-3-(2',4',6'-trimethylphenyl)-3-[N-phenyl-((S)-tert-leucyl)]aminopropionate

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Technology Process of Methyl (S)-dimethyl-3-(2',4',6'-trimethylphenyl)-3-[N-phenyl-((S)-tert-leucyl)]aminopropionate

There total 5 articles about Methyl (S)-dimethyl-3-(2',4',6'-trimethylphenyl)-3-[N-phenyl-((S)-tert-leucyl)]aminopropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 220892-30-8
Methyl (S)-2,2-dimethyl-3-(2,4,6-trimethylphenyl)-3-[N-phenyl-((S)-N',N'-phthaloyl-tert-leucyl)]aminopropionate

: 313478-63-6
Methyl (S)-dimethyl-3-(2',4',6'-trimethylphenyl)-3-[N-phenyl-((S)-tert-leucyl)]aminopropionate

Guidance literature:: Methyl (S)-2,2-dimethyl-3-(2,4,6-trimethylphenyl)-3-[N-phenyl-((S)-N',N'-phthaloyl-tert-leucyl)]aminopropionate; With sodium tetrahydroborate; In water; isopropyl alcohol; at 20 ℃;

With hydrogenchloride; In isopropyl alcohol; at 80 ℃; pH=1; Further stages.;
DOI:10.1002/1521-3765(20000602)6:11<2032::AID-CHEM2032>3.0.CO;2-B

Reference yield:

: 31469-15-5
1-methoxy-2-methyl-1-trimethylsiloxy-1-propene

: 313478-63-6
Methyl (S)-dimethyl-3-(2',4',6'-trimethylphenyl)-3-[N-phenyl-((S)-tert-leucyl)]aminopropionate

Guidance literature:: Multi-step reaction with 2 steps

1.1: CH₂Cl₂ / 72 h / 20 °C

2.1: NaBH₄ / propan-2-ol; H₂O / 20 °C

2.2: 88 percent / aq. HCl / propan-2-ol / 80 °C / pH 1

With sodium tetrahydroborate; In dichloromethane; water; isopropyl alcohol; 1.1: Addition / 2.1: Reduction / 2.2: Hydrolysis;
DOI:10.1002/1521-3765(20000602)6:11<2032::AID-CHEM2032>3.0.CO;2-B

Reference yield:

: 173208-57-6
(S)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3,3-dimethyl-butyryl chloride

: 313478-63-6
Methyl (S)-dimethyl-3-(2',4',6'-trimethylphenyl)-3-[N-phenyl-((S)-tert-leucyl)]aminopropionate

Guidance literature:: Multi-step reaction with 3 steps

1.1: CH₂Cl₂ / 0.67 h / 0 - 20 °C

2.1: CH₂Cl₂ / 72 h / 20 °C

3.1: NaBH₄ / propan-2-ol; H₂O / 20 °C

3.2: 88 percent / aq. HCl / propan-2-ol / 80 °C / pH 1

With sodium tetrahydroborate; In dichloromethane; water; isopropyl alcohol; 1.1: Acylation / 2.1: Addition / 3.1: Reduction / 3.2: Hydrolysis;
DOI:10.1002/1521-3765(20000602)6:11<2032::AID-CHEM2032>3.0.CO;2-B