(S)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3,3-dimethyl-butyryl chloride

Base Information

• Chemical Name: (S)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3,3-dimethyl-butyryl chloride
• CAS No.: 173208-57-6
• Molecular Formula: C₁₄H₁₄ClNO₃
• Molecular Weight: 279.723
• Mol file: 173208-57-6.mol

Synonyms:(S)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3,3-dimethyl-butyryl chloride

Chemical Property of (S)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3,3-dimethyl-butyryl chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3,3-dimethyl-butyryl chloride

There total 1 articles about (S)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3,3-dimethyl-butyryl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phthalic anhydride (85-44-9) → (S)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3,3-dimethyl-butyryl chloride (173208-57-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / Et₃N / toluene / 2 h / Heating

2: PCl₅ / diethyl ether / 2 h / 20 °C

With phosphorus pentachloride; triethylamine; In diethyl ether; toluene;

DOI:10.1039/b509436d

Reference yield: 75.0%

(4,5-dihydro-2-furanyloxy)(trimethyl)silane (51425-66-2) + (E)-N-(2,4,6-Trimethylphenylmethylene)benzenamine (34143-85-6) + (S)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3,3-dimethyl-butyryl chloride (173208-57-6) → 2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3,3-dimethyl-N-[(2-oxo-tetrahydro-furan-3-yl)-(2,4,6-trimethyl-phenyl)-methyl]-N-phenyl-butyramide

Guidance literature:

In dichloromethane; at 25 ℃; for 1h;

DOI:10.1002/(sici)1521-3773(19990115)38:1/2<184::aid-anie184>3.0.co;2-e

Reference yield: 41.0%

benzophenone oxime (1485-71-8) + (S)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3,3-dimethyl-butyryl chloride (173208-57-6) → (S)-(-)-N-benzhydryl-2-(1,3-dioxo-indan-2-yl)-N-hydroxy-3,3-dimethylbutyramide

Guidance literature:

In dichloromethane; at 20 ℃; for 1h;

DOI:10.1021/ja002602o

upstream raw materials:

phthalic anhydride